BACKGROUND In the workup of patients with suspected hereditary nonpolyposis colorectal cancer (HNPCC), detection of loss of heterozygosity (LOH) could help pinpoint the mismatch-repair (MMR) gene carrying the germline mutation, but analysis of microsatellite markers has proved unreliable for this purpose. We developed a simple, low-cost method based on single-nucleotide polymorphism (SNP) genot...

The article introduces the concept of snapshot dynamic indices as centrality measures to analyse how the importance of nodes changes over time in dynamic networks. In particular, the dynamic stress-snapshot and dynamic betweenness snapshot are investigated. We present theoretical results on dynamic shortest paths in firstin first-out dynamic networks, and then introduce some algorithms for comp...

The well known snapshot primitive in concurrent programming allows for n-asynchronous processes to write values to an array of single-writer registers and, for each process, to take a snapshot of these registers. In this paper we provide a formulation of the well known linearizability condition for snapshot algorithms in terms of the existence of certain mathematical functions. In addition, we ...

Static analysis tools, such as OCLE and USE, can be used to analyze structural properties of class models. The USE tool also provides support for analyzing specified operations through interactive simulations in which users provide operation parameters, and manually assign values to state elements to reflect the effect of an operation. In this paper we describe an approach to statically analyzi...

This paper discusses some of the fundamental considerations when managing mining slopes. The goal of management is to reduce all components that contribute to the geotechnical risk and by doing so reduce the risk to as low as reasonably achievable. The techniques and procedures suggested are not exhaustive; they represent a snapshot of some of the practical techniques the author has found usefu...

Many artificial intelligence applications often require a huge amount of computing resources. As a result, cloud computing adoption rates are increasing in the artificial intelligence field. To support the demand for artificial intelligence applications and guarantee the service level agreement, cloud computing should provide not only computing resources but also fundamental mechanisms for effi...

In this paper, we present the design and implementation details of WOWSnap, which is the data backup scheme based on the snapshot approach. As data to be stored in storage subsystems are tremendously increased, data protection techniques have become more important, to provide data availability and reliability. Snapshot is one of such data protection techniques and has been adapted to many file ...

Insects, such as desert ants, employ visual homing strategies for returning to important places in their environment. A model that reproduces aspects of the insects’ navigation behavior is the “snapshot model”. It is based on the assumption that insects store a visual snapshot of the surroundings at the target location, and derive a home direction from a comparison of the current image with thi...

(Middle) Cellular Events in Macroautophagy Macroautophagy (hereafter referred to as autophagy) is a catabolic process in which portions of the cytoplasm are sequestered within double-or multimembraned vesicles termed autophagosomes and then delivered to lysosomes for bulk degradation. The initial phases of macroautophagy consist of the formation of a phago-phore, which is also called an isolati...