bordetella pertussis is a gram negative bacterium that causes respiratory tract infection in human (whooping cough). pertussis toxin (pt) is the main component of current acellular pertussis vaccine and the s1 (subunit1) is the main immunogenic part of it. thus, s1 has been the target of many studies as a potent candidate of acellular vaccine against bordetella pertussis, lacking the side effec...

Ubiquitously encountered in a wide variety of cellular processes, the Grb2-Sos1 interaction is mediated through the combinatorial binding of nSH3 and cSH3 domains of Grb2 to various sites containing PXpsiPXR motifs within Sos1. Here, using isothermal titration calorimetry, we demonstrate that while the nSH3 domain binds with affinities in the physiological range to all four sites containing PXp...

This study investigated the possible roles of strongly binding myosin crossbridges in determining loaded shortening and power output in cardiac myocytes. Single skinned cardiac myocytes were attached between a force transducer and position motor, and shortening velocities were measured over a range of loads during varying levels of Ca(2+) activation. Lowering the [Ca(2+)] slowed shortening velo...

This article proposes offline language-free writer identification based on speeded-up robust features (SURF), goes through training, enrollment, and identification stages. In all stages, an isotropic Box filter is first used to segment the handwritten text image into word regions (WRs). Then, the SURF descriptors (SUDs) of word region and the corresponding scales and orientations (SOs) are extr...

The ability of membrane proteins to sense and respond to changes in membrane voltage is critical for a vast array of biological processes, from generating and propagating the nerve impulse to excitation–secretion coupling. Hodgkin and Huxley (1952) were the first to characterize voltage-activated potassium (Kv) and sodium (Nav) currents, but the common architecture of voltage-activated cation c...

It is easy to deal with a Venn Diagram for 1 ≤ n ≤ 3 sets. When n gets larger, the picture becomes more complicated, that's why we thought at the following codification. That’s why we propose an easy and systematic algebraic way of dealing with the representation of intersections and unions of many sets. Introduction. Let's first consider 1 ≤ n ≤ 9, and the sets S1, S2, ..., Sn. Then one gets 2...

We determine the structure of the homology of the BeckerSchultz space SGiS1) ~ Q(CP^° AS1) of stable Sx-equivariant self-maps of spheres (with standard free S1 -action) as a Hopf algebra over the DyerLashof algebra. We use this to compute the homology of BSGiS1). Along the way, we give a fresh account of the partially framed transfer construction and the Becker-Schultz homotopy equivalence. We ...