Purpose: In this article we studied the effect of the packaging material on the liquid stability of interferon alpha 2b (rhIFN-α2b). Methods: The compatibility of this cytokine with type I borosilicate glass ampoules was evaluated by ELISA and RP-HPLC, at 4oC and after heat sealing. Additionally, the influence of protein concentration (3 and 10 MIU/ml), buffer species (sodium phosphate, sodium ...

Cross-linked cellulose microspheres (CL-CMs) were successfully prepared using an inverse crosslinking suspension method from a cellulose solution with sodium hydroxide/urea aqueous solution as a solvent and epichlorohydrin as the crosslinker. The effects of epichlorohydrin content on the appearance and dispersity, average pore volume, moisture content, and wet real density of CL-CMs were studie...

In this work, the dispersive effect of low molecular weight sodium polyacrylate (PAAS) on serpentine, and its dispersion mechanism were systematically investigated through zeta potential measurements, micro and batch flotation as well as adsorption tests. At pH 5, where flotation of iron sulphide was routinely performed, pyrite and serpentine minerals were oppositely charged, and therefore they...

Nickel ferrite-polyaniline nanocomposite has been prepared and characterized using different techniques. The prepared nanocomposite is used as an adsorbent for the removal of arsenic from aqueous solution of sodium arsenite. The effect of temperature on the equilibrium adsorption of As(III) from aqueous solution on nanocomposite has been investigated. Effect of pH (2-12), contact time (0-70 min...

The potential of surfactant modified zeolites as adsorbents for mycotoxins and as carrier of the pharmaceutical drugs was investigated. Ochratoxin A OCHRA (mycotoxin) and diclofenac sodium DS (anti-inflamatory drug) were used as model substances. Surface of the clinoptilolite was modified with different amounts of quaternary ammonium ions (hexadecyltrimethyl ammonium HDTMA or octadecyldimethylb...

In superconformal filling of copper-chip interconnects, organic additives are used to fill high-aspect-ratio trenches or vias from the bottom up. In this study we report on the development of intermolecular potentials and use molecular dynamics simulations to provide insight into the molecular function of an organic additive (3-mercaptopropanesulfonic acid or MPSA) important in superconformal e...

The effects of ion concentration, pH, and presence of competing ions on the sodium and potassium binding properties of rat liver cell microsomes were studied. Typical adsorption isotherms were obtained in the concentration dependence studies, with saturation being reached when 1.2 to 1.4 m.eq. cations were retained per gm. of microsome Kjeldahl nitrogen. The retention was shown to be due to a b...

In present study 7 carriers such as agar –agarose, wood fiber, wood chips, gelatin, wood powder, calcium alginate and butanol sodium alginate were used for immobilization of fungal amylase. Amylase immobilization was carried out by simple adsorption, adsorption followed by cross-linking, combined adsorption and gel entrapment methods. The suitability of the supports and techniques for the immob...

The paper presents a new model for kinetically controlled adsorption at the fluid/fluid interface. The main purpose of the presented approach is to relate easy to estimate bulk surfactant concentration with Gibbs surface excess. Two adsorption isotherms are involved in the new model development: Frumkin and Szyszkowski isotherms. Additionally the Johannsen time profile of concentration in the a...