OBJECTIVE To investigate the target cells and molecules with sodium valproate induced differentiation of human glioma cells. METHODS Nude mice bearing human glioma xenogenic graft subcutaneously were treated with sodium valproate. The expressions of HDAC1 and Tob genes of xenografts were analyzed with semiquantitative RT-PCR. The CD133+ cells (BTSCs) were isolated from glioma specimens by imm...

PURPOSE This study was undertaken to describe prescribing practice for the anti-convulsant drug (AED) Sodium Valproate (VPA) in an Irish population of woman of childbearing age during the period of the emergence of new data showing a high rate of developmental abnormalities in offspring of women who took VPA during pregnancy. METHODS All prescriptions dispensed from community pharmacies in Ir...

A 34-year-old woman presented with a 3-day history of dyspnea. She denied any preceding fever, night sweats, cough, pleurisy, or coryzal symptoms. was maintained on sodium valproate 800 mg b.i.d., phenytoin 100 o.d., folate 5 and clonazepam 2 nocte for known seizure disorder. Clinical examination radiologic imaging revealed large left-sided pleural effusion the associated collapse left lower lu...

OBJECTIVE Migraine headache is a chronic and disabling condition in adults. Some studies have investigated the efficacy of sodium valproate in the treatment of acute migraine, but the effectiveness and tolerability of intravenous valproate as abortive therapy remains unclear. This study aimed to evaluate the effects of sodium valproate and dexamethasone in the treatment of acute migraine. MET...

Background: Sodium valproate, an anticonvulsant drug, is reported to stimulate Human Immunodeficiency Virus type 1 and Human cytomegalovirus replication. Since epileptic patients undergoing sodium valproate therapy may suffer from various virus infections, the effect of this drug on replication of viruses especially those affecting neuronal tissues such as Herpes simplex virus type 1 is worthy ...

The frequent coexistence of depression in epileptic patients raises the issue of simultaneous use of antidepressants along with antiepileptic drugs in the management of such cases. However, it is necessary to evaluate the safety of these antiepileptic/antidepressant drug combinations. The present study investigates the effect of the antidepressant paroxetine (a selective serotonin reuptake inhi...

Submit Manuscript | http://medcraveonline.com Abbreviations: AEDs: Antiepileptic Drugs; ARBDs: AlcoholRelated Birth Defects; Cd: Cadmium; Dex: Dexamethasone; FAS: Fetal Alcohol Syndrome; GA: Glatiramer Acetate; KT: Ketoconazole; MQ: Mefloquine; MS: Multiple Sclerosis; NO: Nitrous Oxide; NP: Nonylphenol; PTH: Sodium Phenytoin; RA; Retinoic Acid; RA; Rheumatoid Arthritis; SM: Sulfur Mustard; VPA:...

Background: Status epilepticus (SE) is a serious neurological condition and requires prompt treatment. Sodium valproate has been used to treat SE successfully but its role as the first-line antiepileptic drug (AED) is still controversial. We aimed to compare the efficacy of intravenous sodium valproate and phenytoin head-to-head as the firstline AED treatment in SE. Methods: We enrolled patient...

BACKGROUND Sodium valproate inhibits proliferation in neuroblastoma and glioma cells, and inhibits proliferation and induces apoptosis in hepatoblastoma cells. Information describing the molecular pathways of the antitumor effects of sodium valproate is limited; therefore, we explored the mechanisms of action of sodium valproate in the human hepatoblastoma cell line, HepG2. METHODS The effect...