Solid polymer-drug dispersions are used to prepare and stabilize amorphous forms of poorly soluble drugs as a means of improving drug solubility, dissolution and bioavailability. Despite many reports on this subject, solid dispersion dissolution mechanisms have not been well understood. An early study was reported by Simonelli, Mehta and Higuchi (SMH) in 1969 and has served as a model for dispe...

One of the greatest challenges facing the pharmaceutical industry is the design and development of suitable delivery systems to overcome poor dissolution profile for insoluble drugs. Different formulation approaches including particulate systems, pH alterations and co solvents have been investigated in an attempt to determine the critical formulation parameters to improve dissolution and solubi...

Inhalation administration is a promising alternative to the invasive drug delivery methods. The particle size required for ideal drug aerosol preparation is between 1 and 3 μm. The application of microspherical particles of solid dispersions enhances bioavailability of poorly soluble drugs due to the solubilization. In the present work, the spray drying process of the production of microspheric...

Poor aqueous solubility of drugs generally leads to low dissolution rates, poor therapeutic efficiency and low bioavailability. The main aim of this study was to produce physical dispersions of Nimesulide with polymers Eudragit EPO and Mannitol and then subject it for milling, to analyze the role played by different type and concentrations of polymers and the mechanism of impact and attrition m...

Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor drug loading associated with drug-polymer miscibility is major challenge in the downstream processing of ASDs. While many techniques are available converting ASDs into final dosage forms, oral solids remain most viable. The type exc...

Ritonavir is crystalline solid which very slightly soluble in water yet having high dose. This condition necessitates enhancement of solubility before developing into dosage forms. Melt-quenching recently exploring technique for amorphous dispersions (ASDs) drugs to with a hydrophilic carrier enhance solubility. ASDs have drawback poor thermodynamic stability needs be considered. The current wo...

The rapid-release mechanisms of standard extract from Ginkgo biloba leaf (EGb) in the polyethylene glycol (PEG) 6000 dispersions were investigated. The apparent equilibrium solubilities of the total flavone glycosides and the soluble solid materials of EGb increased linearly with the increasing concentrations of PEG 6000 solutions. In DSC curves, the peak, onset and endset temperatures of solid...