The use of laser desorption as a sample introduction method for solid-phase microextraction (SPME) has been investigated in this research project. Three different types of analytical instruments, mass spectrometry (MS), ion mobility spectrometry (IMS) and gas chromatography (GC) were employed as detectors. The coupling of laser desorption SPME to these three instruments was constructed and desc...

We have a sample in front of us. It is of unknown composition, but we know that it is complex, containing anywhere from a few hundred to many thousand chemical components. It is of uncertain physical form perhaps it looks like a liquid, but it has solid particles floating in it. We think that a particular compound is present in that sample, somewhere and in some form, but we don't know how much...

Attosecond science relies on the use of intense, waveform-controlled, few-cycle laser pulses1 to control extreme nonlinear optical processes taking place within a fraction of an optical period. A number of techniques are available for retrieving the amplitude envelope and chirp of such few-cycle laser pulses. However, their full characterization requires detection of the absolute offset between...

The diagnosis of congenital cytomegalovirus (CMV) infection is often accomplished by the detection of circulating antibody directed against CMV. We devised a method for measuring CMV-specific immunoglobulin M (IgM) based on the isolation of IgM antibody by reaction with a solid phase coated with antihuman IgM. The determination of IgM antibody specific for CMV was accomplished by the subsequent...

A review of the many uses of matrix solid phase dispersion (MSPD) in the extraction and analysis of a variety of compounds from a range of samples is provided. Matrix solid phase dispersion (MSPD) has found particular application as a somewhat generic analytical process for the preparation, extraction and fractionation of solid, semi-solid and/or highly viscous biological samples. Its simplicit...