نتایج جستجو برای: soluble fas

تعداد نتایج: 101445  

Journal: :Human molecular genetics 2005
Ming-De Yan Chih-Chen Hong Gi-Ming Lai Ann-Lii Cheng Ya-Wen Lin Shuang-En Chuang

Apoptosis is a morphologically distinct form of cell death involved in many physiological and pathological processes. The regulation of Fas/Apo-1 involved in membrane-mediated apoptosis has also been known to play crucial roles in many systems. More and more naturally occurring antisense RNAs are now known to regulate, at least in part, a growing number of eukaryotic genes. In this report, we d...

Journal: :Journal of immunology 2003
Abdel Rahim A Hamad Abdiaziz S Mohamood Crystal J Trujillo Ching-Tai Huang Emily Yuan Jonathan P Schneck

Fas-mediated apoptosis is a key mechanism for elimination of autoreactive T cells, yet loss of function mutations in the Fas signaling pathway does not result in overt T cell-mediated autoimmunity. Furthermore, mice and humans with homozygous Fas(lpr) or Fas ligand(gld) mutations develop significant numbers of B220+ CD4- CD8- double-negative (DN) alphabeta T cells (hereafter referred to as B220...

Journal: :Investigative ophthalmology & visual science 2005
Clare E Futter Jonathan G Crowston Bruce D S Allan

PURPOSE To investigate the sensitivity of lens epithelial cells (LECs) to Fas-dependent apoptosis and to determine the role of interaction with the extracellular matrix (ECM) in the regulation of Fas-dependent apoptosis. METHODS Sensitivity to Fas-mediated apoptosis of primary human LECs and HLE-B3 LECs cultured on different substrates was determined by Hoechst staining after incubation with ...

Journal: :Diabetes 2000
U Zumsteg S Frigerio G A Holländer

Activated T-cells and macrophages infiltrate pancreatic islets early in the pathogenesis of type 1 diabetes. Their secretion of different pro-inflammatory cytokines such as interleukin (IL)-1beta, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha affects beta-cell function. Here we report that a combination of these cytokines inhibits insulin release, stimulates inducible nitric oxi...

2004
Kristian Hallermalm Anna De Geer Rolf Kiessling Victor Levitsky Jelena Levitskaya

Mechanisms responsible for resistance of tumors to death receptormediated damage by cytotoxic lymphocytes are not well understood. Uveal melanoma cells expressed Fas but were insensitive to Fas triggering induced by bystander cytotoxic T lymphocytes or a Fas-specific agonistic antibody; this could not be ascribed to tumor counterattack against T cells or general resistance of the tumors to apop...

Journal: :Cancer research 2004
Kristian Hallermalm Anna De Geer Rolf Kiessling Victor Levitsky Jelena Levitskaya

Mechanisms responsible for resistance of tumors to death receptor-mediated damage by cytotoxic lymphocytes are not well understood. Uveal melanoma cells expressed Fas but were insensitive to Fas triggering induced by bystander cytotoxic T lymphocytes or a Fas-specific agonistic antibody; this could not be ascribed to tumor counterattack against T cells or general resistance of the tumors to apo...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Thomas K Hoffmann Grzegorz Dworacki Takashi Tsukihiro Norbert Meidenbauer William Gooding Jonas T Johnson Theresa L Whiteside

Spontaneous apoptosis was observed in a proportion of peripheral blood mononuclear cells obtained from patients with head and neck cancer (HNC) but not from normal healthy donors (T. Saito et al., Clin. Cancer Res., 5: 1263-1273, 1999). To further investigate this phenomenon, peripheral blood mononuclear cells were obtained from patients with HNC or normal controls (NCs) and evaluated for expre...

2016
Junya Kuroda Masafumi Taniwaki

Fas is type I membrane protein, expressed on various tissue including hematopoietic cell. Its ligand (FasL), a member of the tumor necrosis factor (TNF) family, which includes two forms of a membrane-bound form and a soluble one, induces apoptosis of Fas-bearing cells through cytotoxic activity. FasL is undetectable in the serum of healthy person, whereas it is high in that from patients with T...

Journal: :Mediators of Inflammation 1998
K Hamzaoui A Hamzaoui L Zakraoui A Chabbou

The aim of this study was to quantify soluble Fas/APO-1 (sFas/APO-1) protein in the serum of patients with Behcet's disease (BD) in active and inactive stages, compared with patients with systemic lupus erythematosus (SLE) and patients with rheumatoid arthritis (RA). Soluble Fas/APO-1 was quantified using a sandwich enzyme-linked immunosorbent assay. Increased serum sFas/APO-1 levels were obser...

Journal: :International immunology 2000
F Puppo P Contini M Ghio S Brenci M Scudeletti G Filaci S Ferrone F Indiveri

In the present study, we have evaluated the apoptotic effect of soluble human MHC class I (sHLA-I) antigens on CD8(+) T lymphocytes. sHLA-I antigens and beta(2)-microglobulin-free HLA class I heavy chains, isolated from serum, induced apoptosis on phytohemagglutinin-activated CD8(+) T lymphocytes in autologous and allogeneic combinations. The extent of CD8(+) T cell apoptosis depends on the deg...

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