Purpose: A comparative study was carried out between surface solid dispersion (SSD) and solid dispersion (SD) of meloxicam (MLX) to assess the solubility and dissolution enhancement approach and thereafter develop as patient friendly orodispersible tablet. Methods: Crospovidone (CPV), a hydrophilic carrier was selected for SSD preparation on the basis of 89% in- vitro MLX adsorption, 19% hydrat...

Purpose: To formulate simvastatin orodispersible tablets with high dissolution rate and enhanced bioavailability. Methods: Simvastatin solid dispersions in βcyclodextrin, hydroxylpropyl-β-cyclodextrin, and hydroxylbutyl-β-cyclodextrin were prepared in different drug: polymer ratios by kneading and solvent evaporation methods. Compatibility was investigated by Differential scanning calorimetry (...

In this study, a significant effect of sodium citrate increasing fenofibrate dissolution has been demonstrated. This effect was dependent on the polymer: drug mixing weight ratio, the sodium citrate type and the method used to disperse the drug with in the polymer. The greater the sodium citrate content the higher the drug dissolution was, up to a maximum corresponding to a polymer: drug ratio ...

Diclofenac sodium is a Non-Steroidal Anti-inflammatory Drug, active against relief from pain and inflammation. The main objective of this research work was to prepare Ethyl Cellulose microsphere loaded with Diclofenac and invitro drug release study. In the present study, emulsion Solvent Evaporation Method is used for preparing microsphere. The polymer (EC) and drug (Diclofenac Sodium) was diss...

The objective of the present investigation was to study the influence of polyethylene glycol 4000 (PEG) and polyvinylpyrrolidone K30 (PVP) on in vitro dissolution of etoricoxib from solid dispersions. Preliminary studies were carried out using a physical mixture of the drug and carriers. Solid dispersions were prepared using the solvent evaporation method. A 32 factorial design was adopted in t...

The present study involves preparation and evaluation of floating microspheres with cimetidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron mic...

A neutron activation analysis method with pre-irradiation separation and post-irradiation purification is presented for the determination of 129I content and 129I/127I ratio in some environmental samples, such as seawater, seaweed, grass and soil. An evaporation concentration followed by solvent extraction was used for the separation of iodine from seawater, and alkaline ashing or alkaline fusi...

With the aim of improving the solubility of ciprofloxacin, polybasic organic acids were utilized to react with ciprofloxacin in different stoichiometric proportions. The use of the solvent drop grinding (SDG) method, as well as the solvent evaporation method, resulted in the crystalline salts ciprofloxacin/fumaric acid (1:1, 2:1), ciprofloxacin/maleic acid (1:1) and ciprofloxacin/citric acid (2...

BACKGROUND A novel lovastatin (LVT)-loaded poly(lactic acid) microsphere suitable for oral administration was developed in this study, and in vitro and in vivo characteristics were evaluated. METHODS The designed microspheres were obtained by an improved emulsion-solvent evaporation method. The morphological examination, particle size, encapsulation ratio, drug loading, and in vitro release w...

Title of Document: STUDY OF THE FEASIBILITY OF CONTROLLING THE LENGTH SCALE OF THE PHASE SEPARATION OF ORGANIC MOLECULAR MIXTURES ON Si(111) SUBSTRATES Miriam Cezza, Doctor of Philosophy, 2014 Directed By: Professor Raymond J. Phaneuf, Department of Materials Science and Engineering We present investigations on the arrangements of phase separating small organic molecules in mixtures subsequent ...