Herein, we report the development of an effective synthetic protocol for synthesis oxindoles in flow based on a C(sp3)–H activation process promoted by supported N-heterocyclic carbene palladium heterogeneous catalytic system using cyclopentyl methyl ether (CPME) as reaction medium. The design catalyst, selection solvent medium, and definition tailored continuous reactor have been all designed ...

The 3' carbon-hydrogen bond of [3'-3H]uridine 5'-triphosphate is is cleaved during its conversion to 2'-deoxyuridine 5'-triphosphate catalyzed by Lactobacillus leichmannii ribonucleoside triphosphate reductase. A selection against 3H of approximately 1.8 is observed on this reduction. During the course of this reaction, no 3H is released to the solvent, and no 3H is recovered in reisolated coen...

Different enantiopure terminal epoxides or bromohydrins have chemoselectively been synthesised in one-pot starting from the corresponding α-bromoketones through alcohol dehydrogenase (ADH)-catalysed processes adding an organic co-solvent and tuning appropriately the medium pH and the temperature. Thus, at neutral pH enantiopure bromohydrins were obtained while using basic conditions (pH 9.5-10)...

• Effect of sample solvent on peak shape in nano- and microflow HILIC was investigated. Sample found to increase the retention time charged compounds. Compounds eluting near were strongly influenced by solvent. A frequently encountered problem practical application hydrophilic interaction chromatography (HILIC) columns is distortion shapes arising from a mismatch between mobile phase. An unmatc...

he Solvent Alternatives GuidE, better known as SAGE, has T been a joint development effort between the Research Triangle Institute and the U.S. Environmental Protection Agency since the guide’s inception in 1992. The SAGE software tool was first released in 1993 and became an immediate success for the identification and selection of alternative nonand low-polluting surface cleaning options. The...

The influence of the solution environment on thermodynamics, crystallizability, and nucleation tolfenamic acid (TFA) in five different solvents (isopropanol, ethanol, methanol, toluene, acetonitrile) is examined using an integrated workflow encompassing both experimental studies intermolecular modeling. solubility TFA isopropanol found to be highest, consistent with strongest solvent–solute int...

Extraction of intracellular lipids the oleaginous yeast Yarrowia lipolytica has been systematically studied aiming towards a sustainable extraction process for lipid recovery. Selection suitable industrial (bulk) solvents and parameters that lead to maximization recovery are significant issues be addressed, with applications motivating this study. Biomass from fermentation (MUCL 28849) was used...

For a range of organic solvents, the likelihood solvent forming solvates has been estimated using recrystallization (RS) data in Cambridge Structural Database (CSD). Although RS are viewed with caution by some crystallographers, most estimates shown to have good precision. Strong trends apparent results. example, high likelihoods found for aromatic solvents electron-withdrawing substituents and...

Rechargeable zinc-ion batteries (RZIBs) are mostly powered by aqueous electrolytes. However, uncontrolled water interactions often confer a small voltage window and poor battery capacity retention. Here, we explore replacing with ethylene glycol as the primary solvent in zinc electrolyte formulations. The assembled reveal suppressed electrolyte-induced parasitic reactions, leading to (1) expand...

Colloidal Quantum Dot Photovoltaics In article number 2203749, Edward H. Sargent, Hyosung Choi, and co-workers demonstrate a random-oriented, but closed-packed organic bulk heterojunction structure realized by solvent selection compositional design. This enables excellent vertical charge conduction ultrafast hole funneling that minimizes recombination. By integrating the film as transport layer...