IMPORTANCE It is important to understand the relationship between sleep medication use and injurious falls in nursing home residents. OBJECTIVE To conduct a case-crossover study to estimate the association between nonbenzodiazepine hypnotic drug use (zolpidem tartrate, eszopiclone, or zaleplon) and the risk for hip fracture among a nationwide sample of long-stay nursing home residents, overal...

quences. The map also gave a very precise estimate of possible especially in problem areas that could be tackled early in the project. The efficacy of this approach is shown in Figure 1. The use of BAC fingerprinting at a genome-wide scale was hence first demonstrated with The sequence of the model plant Arabidopsis thaliana the Arabidopsis project and created the paradigm by was published last...

In order to correctly segregate during mitosis, sister chromatids must attach their kinetochores to stable microtubule (MT) bundles, known as K-fibers, that are connected to opposite spindle poles. In 1986, Marc Kirschner and Tim Mitchison proposed a “search and capture” model in which dynamic MTs emanating from the centrosomes would be selectively stabilized if their plus ends happened to cont...

In eucaryotic cells, the mechanism whereby proteins newly synthesized in the cytoplasm are transferred across cellular membranes is generally thought to involve synthesis of these proteins on ribosomes attached to membranes, primarily of the rough endoplasmic reticulum (RER). Proteins falling into this category, therefore, include those destined for secretion, for transport to inner compartment...

oxisomal matrix proteins are imported into the organelle from their site of synthesis on free cytoplasmic ribo-somes. This observation led to the classical model of peroxisome proliferation in which existing peroxisomes Amherst, Massachusetts 01003 increase in size via the direct import of proteins from the cytoplasm, and divide by fission or budding (La-zarow and Fujiki, 1985). As such, the bi...