During muscle development, an isozymic transition of the glycolytic enzyme enolase occurs from the embryonic and ubiquitous alphaalpha-isoform to the muscle-specific betabeta-isoform. Here, we demonstrate a stimulatory role of thyroid hormones on these two enolase genes during rat development in hindlimb muscles and an inhibitory effect on the muscle-specific enolase gene in cardiac muscle. In ...

Myc-binding protein-1 (MBP-1) is a 37-kDa protein with sequence homology to the 3* portion of the a-enolase gene. a-Enolase is a 48-kDa protein, which plays a critical role in the glycolytic pathway. MBP-1 binds to the c-myc P2 promoter and down-regulates c-myc expression. We have investigated the role of a-enolase in regulation of the c-myc protooncogene. RNase protection assay shows that a-en...

gastric neuroendocrine carcinoma is a rare tumor which has a poor prognosis. herein, we present a 55-year-old woman who presented with complaints of recurrent vomiting, hematemesis and weight loss. endoscopic examination showed a large ulcerated mass in the antrum. microscopic evaluation of the specimen taken through biopsy was compatible with a small round cell tumor. however, definitive histo...

peripheral neuroepitbelioma (pn) is a rare highly malignant tumor, classified in the group of small round cell tumors. we report eight cases of pn, based on histologic appearance and immunohistochemical staining for neuron-specific enolase (nse). electron microscopy was also performed in three cases. the tumors exhibited rapid local growth, leading to limb amputation in five cases. histological...

Enolase is secreted by Candida albicans and is present in its biofilms although its extracellular function is unknown. Here we show that extracellular enolase mediates the colonization of small intestine mucosa by C. albicans. Assays using intestinal mucosa disks show that C. albicans adhesion is inhibited, in a dose dependent mode, either by pretreatment of intestinal epithelium mucosa disks w...

Autistic spectrum disease (ASD) is an increasingly common diagnosis nowadays with a prevalence of 1–2% in most countries. Its complex causality—a combination genetic, immune, metabolic, and environmental factors—is translated into pleiomorphic developmental disorders various severity, which have two main aspects common: repetitive, restrictive behaviors difficulties social interaction varying f...