Background PSA-TRICOM is a vector-based therapeutic cancer vaccine designed to generate a targeted anti-tumor immune response against prostate-specific antigen (PSA)-expressing tumor cells. Early clinical trials have evaluated the impact of this vaccine on the immune system and demonstrated promising clinical activity. Although many patients with prostate cancer are advanced in age, little is k...

Background: Because total prostate-specific antigen (PSA) and, more recently, the percent free PSA are used to screen men for prostate cancer, population-based, ageand racespecific distributions are needed of both PSA tests among American men to estimate the effect of lowering the PSA threshold or widespread introduction of the free PSA test as an additional screening test. Methods: We did PSA ...

Modeling languages are used by software engineers to design and document the structure and behavior of a system. Although many modeling languages have been proposed, Domain-Specific Modeling Languages (DSMLs) have emerged recently due to their simplicity and expressiveness for a particular domain. However, it is not easy for end-users to design and implement DSMLs because DSML development requi...

• Prostate-specific antigen (PSA) is a protein produced by cells of the prostate gland. The PSA test measures the level of PSA in the blood (see Question 1). • The U.S. Food and Drug Administration (FDA) has approved the use of the PSA test along with a digital rectal exam to help detect prostate cancer in men age 50 and older. The FDA has also approved the PSA test to monitor patients with a h...