UNLABELLED The aim of this study was to compare the accuracy and reliability of simple methods of quantifying regional cerebral blood flow (rCBF) with 123I-labeled N-isopropyl-p-iodoamphetamine (IMP) and SPECT and to determine which method was best. METHODS Four methods were examined: (a) the microsphere method with continuous withdrawal of arterial blood, which was based on a microsphere mod...

Medical image reconstruction from projections is computationally intensive task that demands solutions for reducing the processing delay in clinical diagnosis applications. This paper analyzes reconstruction methods combined with preand post-filtering for Single Photon Emission Computed Tomography (SPECT) in terms of convergence speed and image quality. The evaluation is performed by means of a...

UNLABELLED A triple-detector, multipinhole SPECT system was optimally configured to perform simultaneous (201)Tl (stress)/(99m)Tc (rest) myocardial perfusion imaging (MPI) using a protocol that permitted direct diagnostic comparison of this multipinhole SPECT system with conventional rotational SPECT. METHODS Both the rotational and the multipinhole SPECT systems used the same model gamma-det...

Several studies using single photon emission tomography (SPECT) have shown changes in cerebral blood flow (CBF) with age, which were associated with partial volume effects by some authors. Some studies have also demonstrated gender-related differences in CBF. The present study aimed to examine age and gender effects on CBF SPECT images obtained using the 99mTc-ethyl cysteinate dimer and a SPECT...

UNLABELLED A dedicated stationary cardiac single-photon emission computed tomography (SPECT) system with a novel segmented slant-hole collimator has been developed. The goal of this paper is to calibrate this new imaging geometry with a point source. METHODS Unlike the commercially available dedicated cardiac SPECT systems, which are specialized and can be used only to image the heart, our pr...

Objective(s): We recently developed a new uptake index method for 123I-metaiodobenzylguanidine (123I-MIBG) heart uptake measurements by using planar images (radioisotope angiography and planar image) for the diagnosis of Lewy body disease (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies(DLB). However, the diagnostic accuracy of the uptake index was approximately equal to ...

To improve SPECT reconstruction using spatiallycorrelated magnetic resonance(MR) images as a source of side information, one must account for mismatch between MRI anatomical information and SPECT functional information. We investigate an approach which incorporates the anatomical information into SPECT reconstruction by using region labels representing the anatomical regions extracted from MRI....

The registration of multimodal images remains an intricate issue, especially when the multimodal image pair shows non overlapping structures, missing data, noise or outliers. In this paper, we present a deformable model-based technique for the rigid registration of 2 0 and 3D multimodal images. The deformable model embeds a priori knowledge of the spatial correspondence and statistical variabil...

In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regio...

Objective: A novel multifocal collimator, IQ-SPECT (Siemens) consists of cardio-centric and 3D iterative SPECT reconstruction and makes it possible to perform MPI scans in a short time. The aims are to delineate the normal uptake in thallium-201 (Tl) SPECT in each acquisition method and to compare the distribution between new and conventional protocol, especially in patients with normal imaging...