BACKGROUND Ceramide (Cer) and sphingosine (Sph) interfere with critical cellular functions relevant for cancer progression and cell survival. While Cer has already been investigated as a potential drug target for lymphoma treatment, information about the potency of sphingosine is scarce. The aim of this study therefore was to evaluate Sph and its synthetic stereoisomer L-threo-sphingosine (Lt-S...

We prove convergence of the Hamiltonian Particle-Mesh (HPM) method, initially proposed by J. Frank, G. Gottwald, and S. Reich, on a periodic domain when applied to the irrotational shallow water equations as a prototypical model for barotropic compressible fluid flow. Under appropriate assumptions, most notably sufficiently fast decay in Fourier space of the global smoothing operator, and a Str...

Let X be a finite CW-complex. Denote by Sph(X) the abelian group of stable fibre-homotopy classes of spherical fibrations on X. Let F (n) be the monoid of self-homotopy-equivalences of S and let F := colimn→∞ F (n). The classifying space BF represents Sph(X), i.e. Sph(X) ∼= [X;BF ]. For any vector bundle ξ on X, let J(ξ) ∈ Sph(X) be the stable fibre homotopy class of the spherical fibration ξ \...

In this study, we establish a hybrid high-order smoothed particle hydrodynamics (SPH) framework (MLS-TENO-SPH) for compressible flows with discontinuities, which is able to achieve genuine convergence in smooth regions and also capture discontinuities well non-smooth regions. The can be either fully Lagrangian, Eulerian or realizing arbitary-Lagrangian-Eulerian (ALE) feature enforcing the isotr...

This paper presents a hybrid Smoothed Particle Hydrodynamics (SPH) – Finite Element Method (FEM) solver for metal cutting simulations on Graphics Processing Units (GPU). For the first time in chip formation simulation, heat transfer between an SPH model of workpiece, and transient FEM temperature tool, is established. validation, performance modeled thermal contact two numerical domains compare...

I discuss the key features of Smoothed Particle Hydrodynamics (SPH) as a numerical method — in particular the key differences between SPH and more standard grid based approaches — that are important to the practitioner. These include the exact treatment of advection, the absence of intrinsic dissipation, exact conservation and more subtle properties that arise from its Hamiltonian formulation s...

We review recent 3D hydrodynamic calculations of stellar collisions using the Smoothed Particle Hydrodynamics (SPH) method, and we discuss the implications of the results for the formation and evolution of blue stragglers in globular clusters. We also discuss the construction of simple analytic models for merger remnants, approximating the mass loss, shock heating, mixing, and angular momentum ...

The smoothed particle hydrodynamics (SPH) method was employed to simulate the heat transfer process in porous media at pore scale. effective thermal conductivity of a medium can be predicted through simulation experiment SPH. accuracy SPH verified by comparing values with reference for ideal homogeneous and multiphase layered media. 3D experiments were implemented granular generated PFC method....

on SPH to simulate three-dimensional invasion of nonwetting and wetting fluids in fracture apertures with Smoothed particle hydrodynamics (SPH) models were used to complex geometries. Such complex processes are very simulate unsaturated flow in fractures with complex geometries. The SPH is a fully Lagrangian particle-based method that allows the dydifficult to model with traditional grid-based ...

A coupled SPH-DEM based two-dimensional (2-D) micro-scale single cell model is developed to predict basic cell-level shrinkage effects of apple parenchyma cells during air drying. In this newly developed drying model, Smoothed Particle Hydrodynamics (SPH) is used to model the low Reynolds Number fluid motions of the cell protoplasm, and a Discrete Element Method (DEM) is employed to simulate th...