Physical exercise enhances adult neurogenesis in the hippocampus. Running induces the uptake of blood insulin-like growth factor-I (IGF-I) into the brain. A causal link between these two phenomena has been reported; running-induced increases in adult neurogenesis can be blocked by peripheral infusion of anti-IGF-I. Running also alters other aspects of hippocampal structure, including dendritic ...

Cyclin-dependent kinase 5 (Cdk5) activity is dependent on its association with 1 of 2 neuron-specific activators, p35 or p39. Cdk5 and its activators play an important role in brain development as well as higher functions like synaptic plasticity, learning, and memory. Reduction in p35 was reported in postmortem schizophrenia brain, in which reduced dendritic spine density was observed. Previou...

OBJECTIVES Cervical spine disorders are common in the older population. The paravertebral muscles are essential to the support and stabilisation of the cervical spine but have been little studied. The aim was to determine whether pathological changes develop in these muscles in patients with severe cervical spine disease, which, if present, might contribute to the pathogenesis and symptomatolog...

the purpose of this study is to summarize the treatment options for scoliosis and spine deformities from antiquity through medieval times up to the renaissance. furthermore, it is to present the contribution of “the father of modern surgery”, ambroise paré (1510-1590), to this field. paré was a distinguished surgeon of the renaissance with many contributions to surgery, including war trauma, ob...

sex determination is the first step in identification of dead body and hip bone or its components are reliable in sex discrimination. the present study was done to determine the applicability of some osteometric parameters of human hip bone in sex identification. sixteen different variables for the anterior border of 50 human hip bones from a skeletal collection were studied. statistically sign...

The human natural killer-1 (HNK-1) glyco-epitope possesses a unique structural feature, a sulfated glucuronic acid attached to lactosamine on the non-reducing termini of glycans. The expression of HNK-1 is temporally and spatially regulated by glucuronyltransferase (GlcAT-P) in the brain. Our previous report showed that mice lacking GlcAT-P almost completely lost HNK-1 expression in the brain a...