In Mexico mycetomas are mostly produced by Nocardia brasiliensis, which can be isolated from about 86% of cases. In the present work, we determined the sensitivities of 30 N. brasiliensis strains isolated from patients with mycetoma to several groups of antimicrobials. As a first screening step we carried out disk diffusion assays with 44 antimicrobials, including aminoglycosides, cephalosporin...

Liquid-liquid equilibrium (LLE) occurs at a subzero temperature for the acetonitrilewater binary system.When the equilibrium temperature is below its LLE critical temperature of 1.32 C, the top phase is acetonitrile-rich and the bottom phase water-rich. It was observed that a human growth hormone analog with 191 amino acids partitioned exclusively into the bottom phase and its bioactivity was r...

Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center. Their location suggests that they inhibit protein synthesis by blocking the egress of nascent ...

Brucellosis is an endemic zoonosis in Syria, affecting large numbers of animals and there are an increasing number of cases in humans. The aim of this study is to investigate the in vitro efficacy of various traditional and new antibiotics against 89 Brucella isolates (isolated from domestic animals) collected from different Syrian regions. Minimum inhibitory concentrations (MICs) of seventeen ...

Group A Streptococcus (GAS) is one of the major causes of respiratory tract infections. The objectives of this study were to identify isolates of S. pyogenes obtained from respiratory tract infections, and to assess their susceptibility to several antibiotics. A total of 40 strains were isolated and their susceptibility to 17 antibiotics was tested using a standard disk diffusion method. The mi...

Cell extracts of Streptomyces antibioticus, an oleandomycin producer, can inactivate oleandomycin in the presence of UDP-glucose. The inactivation can be detected through the loss of biological activity or by alteration in the chromatographic mobility of the antibiotic. This enzyme activity also inactivates other macrolides (rosaramicin, methymycin, and lankamycin) which contain a free 2'-OH gr...

had similar symptoms five days previously without systemic upset and had not required admission to hospital. On examination she had a temperature of 39°C, a tachycardia, and minimal abdominal tenderness with active bowel sounds. Haematological and biochemical investigations gave normal results. The ratio of T4 to T8 cells was normal at 2-3 (reference range 1-0-2 5). Cefuroxime was started, desf...