OBJECTIVE: Esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and Helicobacter pylori infection remains a neglected topic. The primary objective of this study was to determine the association between Helicobacter pylori infection and esophageal squamous cell carcinoma. A second...

squamous cell carcinoma (scc) is the most common malignant tumor of the oral cavity and one of the ten most common causes of death. it arises from dysplastic oral squamous epithelium. considering the pathogenesis of scc, a smooth and intact surface in this lesion is not a usual finding. in this paper, we report an extremely rare case of oral scc in buccal mucosa presenting as an exophytic lesio...

.. Background: The aim of this study was to evaluate clinico-pathological parameters and the status of argyrophilic nucleolar organizer regions stain in various histological grades of oral squamous cell carcinoma. Materials and Methods: A cross sectional study was conducted on fifty cases of oral squamous cell carcinoma. The specimen were collected from the department of Oral & Maxillofacial Su...

BACKGROUND Resistance to anticancer agents is a major obstacle for successful chemotherapy in tongue squamous cancer. Sam68 is an oncogenic-related protein in oral tongue squamous cell carcinoma functions as a signaling molecule mediating apoptosis, whose over-expression is associated with the clinicopathologic characteristics and prognosis of patients. The present study was to examine the effe...

β-Catenin acts as a structural protein at cell-cell adherens junctions and as a transcription activator mediating Wnt signal transduction. Altered β-catenin expression has been associated with loss of cell differentiation and acquisition of an invasive phenotype. In the present study, β-catenin expression was compared immunohistochemically between oral squamous cell carcinoma (30 cases) and ver...

OBJECTIVE To compare the repetitive DNA patterns of human actinic keratoses and squamous cell carcinomas to determine the genetic alterations that are associated with malignant transformation. INTRODUCTION Cancer cells are prone to genomic instability, which is often due to DNA polymerase slippage during the replication of repetitive DNA and to mutations in the DNA repair genes. The progressi...

BACKGROUND AND PURPOSE Human papillomavirus-associated oropharyngeal squamous cell carcinoma is increasing in prevalence and typically occurs in younger patients than human papillomavirus-negative squamous cell carcinoma. While imaging features of human papillomavirus-positive versus human papillomavirus-negative squamous cell carcinoma nodal metastases have been described, characteristics dist...