Introduction: Intra-platelet serotonin has been implicated in the process of liver regeneration and development disease recurrence after resection for malignant diseases. While effect on tumor promotion were only observed independent experiments, we recently demonstrated a bivalent association patients undergoing resection. This raised question whether pharmacologic modification intra-platelet ...

Introduction Recent studies have supported that Lactobacillus plantarum can reduce the severity of anxiety and depression. However, previous did not focus on sleep quality. This study determines whether Plantarum CECT7485 Brevis CECT7480 insomnia, improves quality in patients who comorbidity depression disorders. Objectives An assessment insomniac effects a probiotic supplement containing (PLAN...

PICO question
 Does administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine reduce severity and / or frequency some anxiety related behaviours in companion dogs, at least 8 months age, when compared with no pharmacological treatment?
 
 Clinical bottom line
 Category research Treatment
 The number type study designs reviewed
 Two studies, bot...

The aim of this study was to compare the effectiveness of attribution retraining group therapy (ARGT) with selective serotonin reuptake inhibitors (SSRIs) in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and obsessive-compulsive disorder (OCD). Subjects were sequentially recruited and randomized into two groups, one receiving ARGT (n = 63) and the other S...

Serotonin uptake, mediated by the serotonin transporter (SERT), is blocked acutely by antidepressants such as the selective serotonin reuptake inhibitors (SSRIs), but such blockade does not correlate temporally with the onset of therapeutic improvement. Treatment with SSRIs for 21 d induced downregulation of the SERT (Benmansour et al., 1999). The time course of SERT downregulation as well as t...

It is known that newer antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs), provide advantages in tolerability over antidepressants such as the tricyclics. However, even within the SSRI class, differences in efficacy or tolerability exist between the individual drugs. Among the three most widely prescribed SSRIs are paroxetine, sertraline, and escitalopram. Escitalopram...

INTRODUCTION Selective serotonin reuptake inhibitors (SSRIs) differ in the severity of induced ejaculation delay. Various studies indicate that oxytocin is involved in sexual behavior. AIM To review and evaluate the involvement of oxytocin in SSRI-induced ejaculation delay. MAIN OUTCOME MEASURES Oxytocine release, 5-hydroxytryptamine (5-HT) neurotransmission, and desensitization of 5-HT(1A)...

There is a substancial body of literature demonstrating the efficacy of selective serotonin reuptake inhibitors antidepressants (SSRI) in reducing binge eating and vomiting frequency in Bulimia Nervosa. Good therapeutic response to noradrenergic agents, like desipramine and reboxetine, though not frequently reported in literature, has already been demonstrated. This case report describes the tr...

OBJECTIVE To investigate whether exposure to selective serotonin reuptake inhibitors (SSRIs) in early pregnancy is associated with miscarriage. METHODS This was a nationwide cohort study identifying all registered pregnancies in Denmark from 1997 to 2010. All births were identified using the Medical Birth Registry, and all records of induced abortion or miscarriage were gathered from the Nati...