ETHE1 is an iron-containing protein from the metallo β-lactamase family involved in the mitochondrial sulfide oxidation pathway. Mutations in ETHE1 causing loss of function result in sulfide toxicity and in the rare fatal disease Ethylmalonic Encephalopathy (EE). Frequently mutations resulting in depletion of ETHE1 in patient cells are due to severe structural and folding defects. However, some...

Hybrid intra-data centre networks, with optical and electrical capabilities, are attracting research interest in recent years. This is attributed to the emergence of new bandwidth greedy applications and novel computing paradigms. A key decision to make in networks of this type is the selection and placement of suitable flows for switching in circuit network. Here, we propose an efficient strat...

The Swiss financial centre, as it developed during the twentieth century, has for a long time been presented and perceived singularly stable solid environment escaping crises restructuring. This view, promoted by dominant actors – private banks, cantonal banks large commercial presenting their own development, in teleological vision, success stories , is strongly challenged more recent research...

While walking on an instrumented treadmill, 20 subjects were perturbed by lateral sinusoidal oscillations representative of those encountered in transport: frequencies in the range 0.5-2 Hz and accelerations in the range 0.1-2.0 ms(-2) r.m.s., corresponding to velocities in the range 0.032-0.16 ms(-1) r.m.s. Postural stability was assessed from the self-reported probability of losing balance (i...

Stereogenic silicon centres in functionalised tetracoordinated organosilanes generally exhibit very high configurational stability under neutral conditions. This drops completely when higher coordination states of the centre are reached due to rapid substituent exchange. Herein we describe synthesis chiral and pentacoordinate derivatives with stability. The zwitterionic nature these air- water-...

John M. Pandolfi* and Jeremy B.C. Jackson Centre for Marine Studies and Department of Earth Sciences, ARC Centre of Excellence for Coral Reef Studies, The University of Queensland, St Lucia, Qld 4072, Australia Center for Marine Biodiversity and Conservation, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA; and Center for Tropical Paleoecology an...

AIM To determine the diversity and stability of cultured vaginal lactobacilli in a multi-ethnic population of pregnant women. METHODS AND RESULTS A single-centre, prospective, cohort study was performed in a tertiary perinatal centre in East London, UK. Self-collected vaginal swabs at 13 and 20 weeks gestation were obtained from women attending for routine antenatal care and cultured for lact...

The purpose of this study was to examine the characteristics of centre of pressure (COP) and centre of mass (COM) fluctuations in ballet dancers standing quietly. Ten healthy young women performing classic ballet dance as recreational exercise (dancer group) and 10 healthy non-ballet dancers young women who were not ballet dancers (control group) participated in this study. Participants were in...