Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of magnitude, for reasons that remain unclear. An example is the pair of N-(2'-deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF) and N-(2'-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) adducts that differ by a single acetyl group. The NER efficiencies in human HeLa cell extracts of these lesions are significant...

In both DNA and RNA, stretches of guanine bases can form stable four-stranded helices in the presence of sodium or potassium ions. Sequences with a propensity to form guanine tetraplexes have been found in chromosomal telomers, immunoglobulin switch regions, and recombination sites. We report the crystal structure at 0.95 A resolution of a parallel-stranded tetraplex formed by the hexanucleotid...

Thin prepregs with thickness of less than 0.06 mm support flexible lamination design because it is possible to apply various stacking sequences. The objective this study elucidate the effects layer and sequence on open-hole compressive (OHC) strength for thin-ply carbon fiber reinforced plastic composite (CFRP) laminates. Details OHC CFRP laminates were evaluated experimentally. Furthermore, fi...

We introduce a coarse-grained RNA model for molecular dynamics simulations, RACER (RnA CoarsE-gRained). RACER achieves accurate native structure prediction for a number of RNAs (average RMSD of 2.93 Å) and the sequence-specific variation of free energy is in excellent agreement with experimentally measured stabilities (R2 = 0.93). Using RACER, we identified hydrogen-bonding (or base pairing), b...

In shallow water the frequency domain controlled source electromagnetic method is subject to airwave saturation that strongly limits the sensitivity to resistive hydrocarbon targets at depth. It has been suggested that time-domain CSEM may offer an improved sensitivity and resolution of these deep targets in the presence of the airwave. In order to examine and test these claims, this work prese...

In this paper, we present a generic method/model for multi-objective design optimization of laminated composite components, based on Vector Evaluated Artificial Bee Colony (VEABC) algorithm. VEABC is a parallel vector evaluated type, swarm intelligence multi-objective variant of the Artificial Bee Colony algorithm (ABC). In the current work a modified version of VEABC algorithm for discrete var...

Impact damage characteristics and compression after edge-on impact (CAEI) strength of CFRP laminates were experimentally investigated. with various thicknesses stacking sequences prepared. tests a constant energy level performed using the special fixtures. The damaged areas their shapes on evaluated an ultrasonic C-scanning machine. It was observed that thickness affected delamination shape, wh...

for any lacunary sequence $theta = (k_{r})$, we define the concepts of $s_{theta}-$limit point and $s_{theta}-$cluster point of a sequence of fuzzy numbers $x = (x_{k})$. we introduce the new sets  $lambda^{f}_{s_{theta}}(x)$, $gamma^{f}_{s_{theta}}(x)$ and prove some inclusion relaions between these and the sets $lambda^{f}_{s}(x)$, $gamma^{f}_{s}(x)$ introduced in ~cite{ayt:slpsfn} by aytar [...

In this paper, a method to compute explicit solutions for laminated plate with arbitrary stacking sequences is presented. This technique is based on the construction of an a posteriori Reduced-Order Model using the so-called Proper Generalized Decomposition. The displacement field is approximated as a sum of separated functions of the in-plane coordinates x; y, the transverse coordinate z and t...

the principal effects of mass degradation on polymer matrix composites (pmcs) are the decay of mechanical properties such as strength, elongation, and resilience. this degradation is a common problem of the pmcs under thermal cycling conditions. in this article, composite degradation was investigated by measurement of total mass loss (tml) using the taguchi approach. thermal cycling tests were ...