In the epidermis, p53 plays an important role in UV-B protection that led us to examine the role, if any, that p63, a p53 homologue highly expressed in the basal layer of the epidermis, might play in the epidermal UV-B response. One p63 isoform, deltaNp63alpha, decreased dramatically in normal keratinocytes or newborn epidermis at both the protein and RNA levels after UV-B irradiation. In an at...

Zebrafish epidermal ionocytes are analogous to mammalian kidney cells in terms of expression and function of ion transporters. In this review, we summarize current findings about the development of the zebrafish epidermis and demonstrate how the zebrafish regulate stress acclimation through induction of cell differentiation. In addition, cellular homologies between zebrafish epidermal ionocytes...

When the whole skin of embryonic chickens is grown in culture, epidermal differentiation quite closely resembles that in vivo (Miszurski, 1937; Fell, 1957; Wessells, 1961). Separated epidermis, however, lacking its connective tissue, develops less well; in hanging drop cultures it may be maintained occasionally as an epithelial sheet which does not differentiate (Champy, 1914; Drew, 1922; McLou...

Inflammasome activation is needed for the production of IL-1 family cytokines IL-1β and IL-18. Both these have been suggested to influence inflammatory responses in AD, as well genetic association AD with polymorphisms IL18R1 IL18RAP genes has proposed. In this study, we report increased expression inflammasome sensor NACHT, LRR, PYD domains-containing protein 1 (NLRP1) adapter CARD Domain Cont...

Dorsal closure (DC) is an essential step during Drosophila development whereby a hole is sealed in the dorsal epidermis and serves as a model for cell sheet morphogenesis and wound healing. It involves the orchestrated interplay of transcriptional networks and dynamic regulation of cell machinery to bring about shape changes, mechanical forces, and emergent properties. Here we provide insight i...

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important pathogens that cause nosocomial infections. However, microbiological culture techniques take a few days to yield results; therefore, a simple, cost-effective, and rapid detection system is required for screening for MRSA and related bacteria: Methicillin-resistant Staphylococcus epidermidis (MRSE) carriers during th...

Background: The ultrasonography probes are cleaned by absorbent soft, dry cloth. This question arose whether linear and convex ultrasound probes coupling with gel could perform as a means for nosocomial infections transmission, and which method is economical and more efficient for cleaning the probes. This study was conducted to answer these questions. Methods: One hundred – ninety two patients...