Induced pluripotent stem cells (iPSC) have been generated from somatic cells by introducing reprogramming factors. Integration of foreign genes into the host genome is a technical hurdle for the clinical application. Here, we show that Sendai virus (SeV), an RNA virus and carries no risk of altering host genome, is an efficient solution for generating safe iPSC. Sendai-viral human iPSC expresse...

Statistical modelling of the magnitude and frequency extreme observations is fundamental for a variety sciences. In this paper, we develop statistical methods similarity-based clustering heteroscedastic extremes, which allow us to group time series independent according their extreme-value index scedasis function (i.e., values, respectively). Clustering functions indices involves challenge grou...

Multivariate extreme value theory and methods concern the characterization, estimation and extrapolation of the joint tail of the distribution of a d-dimensional random variable. Existing approaches are based on limiting arguments in which all components of the variable become large at the same rate.This limit approach is inappropriate when the extreme values of all the variables are unlikely t...

Given a sample of n observations y1, . . . , yn at time points t1, . . . , tn we consider the problem of specifying a function f̃ such that f̃ • is smooth, • fits the data in the sense that the residuals yi − f̃(ti) satisfy the multiresolution criterion

The analysis and modeling of extreme values have traditionally relied on extreme value theory (EVT), which in turn has tended to focus on limiting or asymptotic cases and assumptions of independence. However, disciplines from climate science and digital mapping to infrastructure security and transportation, have been generating massive volumes of data with multidimensional and multivariable dep...