Integrin alpha(5)beta(1) is expressed on several types of cancer cells, including colon cancer, and plays an important role in tumor growth and metastasis. The ability to target the integrin alpha(5)beta(1) using an appropriate drug delivery nano-vector can significantly help in inhibiting tumor growth, reducing tumor metastasis, and decreasing deleterious side effects associated with different...

Transport of the organic molecule malachite green, across a bilayer of dioleoylphosphatidylglycerol liposome in aqueous Ž . solution, has been observed using a new method, namely second harmonic generation SHG . Following the rapid mixing of liposome and malachite green solutions, a decay of the SHG signal in time is observed as the malachite green bound to the outer liposome surface crosses to...

We study the spectrum of gravitational perturbations around a vacuum de Sitter brane in a 5D asymmetric braneworld model, with induced curvature on the brane. This generalises the stealth acceleration model proposed by Charmousis, Gregory and Padilla (CGP) which realises the Cardassian cosmology in which power law cosmic acceleration can be driven by ordinary matter. Whenever the bulk has infin...

This work was supported by the Stiftung Mainzer Herz and the Robert Müller Stiftung. Further support was provided by the Center for Translational Vascular Biology (CTVB), the German Center vor Cardiovascular Research (DZHK), and the Center for Thrombosis and Hemostasis (CTH). T.M. is PI oft he DZHK. C.M. is supported by the Deutsche Forschungsgemeinschaft (DFG; Heisenberg Programm and SFB 894),...

Liposomal nanoparticles are versatile drug delivery vehicles that show great promise in cancer therapy. In an effort to quantitatively measure their in vivo pharmacokinetics, we developed a highly efficient 89Zr liposome-labeling method based on a rapid ligand exchange reaction between the membrane-permeable 89Zr(8-hydroxyquinolinate)4 complex and the hydrophilic liposomal cavity-encapsulated d...

background it has been shown that topical nanoliposomal formulations improve burn healing process. on the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption there is not such data available for burn eschar. present investigation studies permeation of clindamycin phosphate (cp) through burn eschar from li...

Liposomes as targeted drug delivery systems are an emerging strategy in the treatment of cancer to selectively target tumors or genes. In this study, we generated the recombinant protein, EC1-GLuc, by fusing the EC1 peptide, an artificial ligand of ErbB2, with Gaussia luciferase (GLuc). The purified EC1-GLuc was conjugated with a nickel-chelating liposome to construct the EC1-GLuc-liposome. In ...

We sought to determine the efficacy of atomized paclitaxel liposome inhalation treatment of pulmonary fibrosis in a bleomycin-induced rat model. Forty male Sprague-Dawley rats were randomly divided into four groups: healthy control, pulmonary fibrosis without treatment, paclitaxel liposome inhalation-treated, and intravenous paclitaxel liposome-treated. Fibrosis was induced by bleomycin injecti...