Aim of the study Recently, novel serum markers modified by the body mass index z-score (BMI z-score) were proposed as a reliable noninvasive alternative for the detection of significant fibrosis and steatosis in children with chronic hepatitis C (CHC). The aim of this study was to evaluate the clinical usefulness of these biomarkers. Material and methods Thirty children aged 9.4 ± 3.7 years (...

BACKGROUND To assess the clinical validity of controlled attenuation parameter (CAP) in the diagnosis of hepatic steatosis in a series of overweight or obese children by using the imperfect gold standard methodology. METHODS Consecutive children referred to our institution for auxological evaluation or obesity or minor elective surgery were prospectively enrolled. Anthropometric and biochemic...

Methods Between April 2011 and March 2013, 210 consecutive patients with chronic viral hepatitis were submitted. Patients with excessive alcohol consumption (above 20 g/ day for males, 10 g/day for females) have been excluded. The steatosis, necroinflammatory activity and fibrosis were estimated using FibroMax (non-invasive liver tests). The serological and virological tests established the dia...

Non-alcoholic fatty liver disease (NAFLD) is emerging as a major health problem worldwide. NAFLD is a continuum of disease ranging from mild liver steatosis to severe steatohepatitis, which will ultimately lead to end-stage liver disease with high morbidity and mortality rates. This disorder is considered as a silent liver disease. The metabolic syndrome and its components are accounted as the ...

Objective was to conduct a comparative analysis of routine clinical and laboratory parameters in two groups patients with chronic viral hepatitis C (CHC) depending on the presence or absence hepatic steatosis. Methods materials. The observational retrospective cross-sectional study included 411 CHC, which 43.80 % were those studied parameters, genotype, as well formalized results liver biopsy u...

Hepatic steatosis is a commonly noticed and most prevalent condition among donated liver grafts. The pressing demand for organs and increased patient death rates while awaiting organ transplantation has led to the use of cadaveric livers with hepatic steatosis for transplantation. Recent data reported the use of steatotic liver grafts in 71% of cases (Noujaim et al., 2009). Moreover, to meet th...

background often, there is no access to sufficient sample size to estimate the prevalence using the method of direct estimator in all areas. the aim of this study was to compare small area’s bayesian method and direct method in estimating the prevalence of steatosis in obese and overweight children. materials and methods: in this cross-sectional study, was conducted on 150 overweight and obese ...

background oral administration of pro- and prebiotics has recently been considered as an effective way for nonalcoholic fatty liver disease (nafld) recovery. objectives the current study aimed at evaluating the effect of supplementation with probiotics and/or prebiotics on liver function tests in patients with nafld. methods in this double blind, placebo-control clinical trial, 75 subjects with...

endoplasmic reticulum (er) stress provides abnormalities in insulin action, inflammatory responses, lipoprotein b100 degradation and hepatic lipogenesis. excess accumulation of triglyceride in hepatocytes may also lead to disorders such as non-alcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash). opioid peptides are involved in triglyceride and cholesterol dysregulat...

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs in the world. Despite its pharmacological importance, it may cause liver toxicity and steatosis through mitochondrial dysfunction. The aim of this study is to further investigate VPA-induced mechanisms of steatosis by analyzing changes in patterns of methylation in nuclear DNA (nDNA) and mitochondrial DNA (mtDNA). Ther...