OBJECTIVE To review the frequency of use, possible efficacy and safety profile of Prothrombinex-HT (CSL Bioplasma, Melbourne, VIC) in treatment of patients with microvascular bleeding refractory to standard measures after cardiothoracic surgery. METHODS A retrospective chart review was performed of 60 consecutive cardiothoracic surgical patients who received Prothrombinex-HT between February ...

BACKGROUND Polypharmacy is a significant economic burden. OBJECTIVE We tested whether using reverse auction (RA) as compared with commercial pharmacy (CP) to purchase medicine results in lower pharmaceutical costs for heart failure (HF) and heart transplantation (HT) outpatients. METHODS We compared the costs via RA versus CP in 808 HF and 147 HT patients followed from 2009 through 2011, an...

The objectives of this review are twofold. Our first objective is to evaluate the evidence supporting a role for genetics in irritable bowel syndrome (IBS). Specific examples of the associations of genetic variation and symptoms, syndromes, and intermediate phenotypes, including neurotransmitter (serotonergic, α(2)-adrenergic, and cannabinoid) mechanisms, inflammatory pathways (IL-10, TNFα, GNβ...

Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use disorder with significant morbidity. Major advances have been made in delineating neurobiological mechanisms of cocaine abuse; however, effective medications to treat cocaine use disorder remain to be discovered. The present review will focus on the role of serotonin (5-HT; 5-hydroxytryptamine) neurotransmis...

Tear of the anterior cruciate ligament (ACL) is the most common ligamentous injury of the knee. Reconstructing this ligament is often required to restore functional stability of the knee. Many graft options are available for ACL reconstruction, including different autograft and allograft tissues. Autografts include bone-patellar tendon-bone composites (PT), combined semitendinosus and gracilis ...

C-reactive protein (CRP), an acute-phase reactant, has been identified as a saliva-based biomarker of inflammation. The objective of the study was to estimate and compare salivary CRP levels in Hashimoto's thyroiditis (HT) and Subacute thyroiditis (SAT). The study included 30 HT patients who presented with clinical features of hypothyroidism, 15 SAT patients who presented with clinical features...

Introduction: The cerebral 5-HT system is phylogenetically old and shows remarkable anatomical resemblance among species. The goal of this review is to investigate the physiological role of 5-HT in the accomplishment of behavioral states. Tryptophan and 5-HT: In higher organisms, tryptophan is an essential amino acid and is also the least abundant of the natural amino acids. Its catabolism is, ...

The serotonergic (5-HT) system in the brain is involved in the modulation of offensive aggressive behavior. The dogma that activity of the 5-HT system is inversely related to aggression is obsolete now. Research on the status of the 5-HT system before, during and after the execution of aggression is ongoing but has not yet led to a clear picture about the actual functional role of the 5-HT syst...

Thyroid squamous cell carcinoma is very rare. At present, it limited to case reports. Since the thyroid follicular epithelium non-squamous epithelium, how primary (SCC) of occurs still a controversial issue. Hashimoto’s thyroiditis (HT) considered be an independent risk factor for cancer, under basis HT, tumor cells evolve and develop papillary (PTC), particularly de-differentiate into SCC elus...

PurposeThe prevalence of using endomyocardial biopsy (EMB) or gene expression profiling and donor derived cell-free DNA, i.e. HeartCare (HC), varies greatly among programs in the US. This study aims to determine if frequency surveillance after HT correlates with clinical outcomes.MethodsPatients from multi-center Surveillance Outcomes Registry (SHORE) at least 1 year follow-up were included. Mu...