The Alcohol Needs Assessment Project estimated that 20% of people aged ≥55 years consume alcohol at levels hazardous to their health, which is associated with a wide range of physical, psychological, and social problems, including coronary heart disease, hypertension, stroke, liver disease, and increased risk of a range of cancers. The Alcohol—Evaluating Stepped Care for Older Populations (AESO...

The Hypertension Detection and Follow-up Program followed up 10,940 persons for 5 years in a community-based, randomized, controlled trial of treatment for hypertension. Participants were randomized to one of two treatment groups, stepped care and referred care. The primary end point of the study was all-cause mortality, with morbid events involving the heart, brain, and kidney as secondary end...

In stepped cluster designs the intervention is introduced into some (or all) clusters at different times and persists until the end of the study. Instances include traditional parallel cluster designs and the more recent stepped-wedge designs. We consider the precision offered by such designs under mixed-effects models with fixed time and random subject and cluster effects (including interactio...

nowadays, tube bonding in vehicles structure is noticeably considered by many researches. in this paper, local tube compression process by a rubber ring has been studied. firstly, simulation of the process was performed by fem. then, experimental test has been carried out to validate the numerical results. numerical and experimental results were compared showing a good agreement. in the second ...

BACKGROUND Global mental health is a growing field intricately connected to broader health, violence and economic issues. Despite the high prevalence and cost of mental health disorders, an estimated 75 % of those with need in lower resource settings do not receive intervention. Most studies to date have examined the effectiveness of single-disorder mental health treatments - an approach that m...

Complier average causal effects (CACE) estimate the impact of an intervention among treatment compliers in randomized trials. Methods used to estimate CACE have been outlined for parallel-arm trials (e.g., using an instrumental variables (IV) estimator) but not for other randomized study designs. Here, we propose a method for estimating CACE in randomized stepped wedge trials, where experimenta...

BACKGROUND This study compared the best available treatment for bulimia nervosa, cognitive-behavioural therapy (CBT) augmented by fluoxetine if indicated, with a stepped-care treatment approach in order to enhance treatment effectiveness. AIMS To establish the relative effectiveness of these two approaches. METHOD This was a randomised trial conducted at four clinical centres (Clinicaltrial...

Previous studies demonstrated an aftereffect of walking on a rotating treadmill, involving inadvertent circular navigation with eyes closed [podokinetic after-rotation (PKAR)]. We compared PKAR following unilateral and bilateral podokinetic (PK) stimulation to determine whether the left and right legs could be independently adapted. Each subject performed two sessions of PK stimulation, steppin...

Traditional stepped frequency chirp pulse train methods suffer from high sidelobes and ambiguous peaks, known as grating lobes and difficulty in compensating Doppler effect caused by target motion. This paper investigates a class of non-linear stepped frequency chirp pulse train with low sidelobes and capability to cancel clutter and to compensate motion. We present analytic expression for its ...

recently, particular attention has been paid to the stepped spillways due to the increasing effect of energy dissipation and the reduction of cavitations risks with the development of roller compacted concrete (rcc) technique. flow regimes on the spillways divide into three groups, namely skimming, jet and transition flow. compared to the numerical methods, the majority of performed studies in ...