Background: Most research on autonomic dysfunction of diabetes mellitus is conducted on ganglions innervating gastrointestinal (GI) tract and there are limited works focusing on cervical sympathetic ganglia. The effects of diabetes mellitus (DM) on the neurons of superior cervical sympathetic ganglion (SCSG) are investigated by stereological methods. Material and Methods: Female rats (n=72) ran...

Radiation-induced autophagy mediates susceptibility to radiation [1]. However, autophagy is a multifaceted process. Herein, 2 aspects of autophagy, induction of autophagy or changes in autophagic flux, in radiation sensitivity were investigated. Relying on a systems-based approach and adding to a large, data dense morphome database [2, 3], we mined for complex cellular information on autophagy ...

Transmission electron microscopy (EM) can acquire images in which a range of subcellular organelles are clearly resolved simultaneously. There exist mature stereology techniques for extracting quantitative specimen information from section-based EM images and such techniques have been adopted successfully for use in immuno-EM. A bottleneck preventing the application of these nanomorphomics meth...

Keratinocyte growth factor (KGF) is a potent mitogen of pulmonary bronchial and alveolar epithelial cells. However, it is unclear which type(s) of airway epithelial cells (AEC) proliferate(s) in response to KGF. AEC proliferation was induced in rats by either endobronchial instillation of 5 mg recombinant human (rHu) KGF per kg body weight or by adenoviral transfer of the human KGF gene (Ad5-Hu...