OBJECTIVE Stereotactic radiosurgery for vestibular schwannoma entails uncertain long-term risk of tumor recurrence and delayed cranial neuropathies. In addition, the underlying histopathologic changes to the tumor bed are not fully characterized. We seek to understand the clinical and histologic features of recurrent vestibular schwannoma after stereotactic radiation therapy. STUDY DESIGN Ret...

OBJECTIVE Several treatment options have proven effective for metastatic brain tumors, including surgery and stereotactic radiosurgery. Tumors with cystic components, however, are difficult to treat using a single method. We retrospectively assessed the outcome and efficacy of gamma knife radiosurgery (GKRS) for cystic brain metastases after stereotactic aspiration of cystic components to decre...

nelson’s syndrome nowadays a rare entity results from an adrenocorticotropin (acth)–secreting pituitary adenoma in patients with refractory cushing's disease after a therapeutic bilateral adrenal gland removal. we report a case of 25 year old female with cushing’s disease who was initially managed with medical treatment, but in view of severe persistent hyper cortisol state was subjected t...

The aims of radiation therapy of brain metastases include maintaining neurocognitive function and control of disease and, hopefully, improvement of survival. We present a case report with a very long survival in which the role of repeated stereotactic radiosurgery (SRS) was investigated for a patient with a recurrent brain metastasis from non-small cell lung cancer in the same area. Stereotacti...

OBJECTIVE During an 8-year interval, we evaluated the survival benefit of stereotactic radiosurgery performed in 64 patients with glioblastomas multiforme (GBM) and 43 patients with anaplastic astrocytomas (AA). METHODS Adjuvant radiosurgery was performed either before disease progression or for recurrent tumor at the time of disease progression. Clinical and imaging follow-up data were obtai...

Stereotactic body radiation therapy (SBRT) is a newly developed technique currently in clinical use. SBRT originated from stereotactic radiosurgery for intracranial tumors. SBRT has been widely used clinically for lung cancer. The practice of SBRT demands different kinds of patient fixation, breathing control, target determination, treatment planning, and verifications. The history and current ...

Stereotactic radiosurgery (SRS) has been an effective modality for the treatment of benign and malignant cranial disease for over 50 years. Just as SRS revolutionized the practice of neurosurgery, stereotactic ablative radiotherapy (SAbR) in extracranial sites is now challenging conventional wisdom with regard to the practice of radiation oncology. This clinical paradigm change has been enabled...

pathological hormone secretion, the clinical presentation is determined by localization of tumor. Common symptoms include headache and visual field defects. This review addresses pathology aspects diagnosis, conservative treatment, methods radiation therapy. Drug therapy endocrine-inactive adenomas based on presence receptors for somatostatin dopamine in pituitary adenoma cells. Data stereotact...

The developments of medicine always follow innovations in science and technology. In the past decade, such innovations have made cancer-related targeted therapies possible. In general, the term "targeted therapy" has been used in reference to cellular and molecular level oriented therapies. However, improvements in the delivery and planning of traditional radiation therapy have also provided ...

PURPOSE To systematically review the evidence for the use of stereotactic radiosurgery or stereotactic fractionated radiation therapy in adult patients with malignant glioma. METHODS Key clinical questions to be addressed in this evidence-based review were identified. Outcomes considered were overall survival, quality of life or symptom control, brain tumor control or response and toxicity. M...