When injected directly into spinal tissue, poly(lactide-co-glycolide) (PLGA) particles have the potential to provide sustained delivery of proteins necessary to promote nerve regeneration. To ensure the injection of sterile particles, a novel decontamination method was developed that can inactivate bacteria while maintaining particle and protein integrity. This method involves the resuspension ...

The study aims to investigate a cost-effective approach to convert non-pretreated rice straw hydrolysate into biobutanol. The influences of the initial cell concentration and incubation temperature on biobutanol production were evaluated under both sterile and non-sterile conditions. Results indicate that 100% glucose utilization could be achieved for initial cell concentrations greater than 21...

Schizophrenia is a severe mental illness with a lifetime prevalence of approximately one percent worldwide. Maintenance antipsychotic treatment has been effective in preventing relapses in long-term follow-up studies. Logically it can be proposed that long-acting injectable antipsychotics (LAI) might reduce both unintentional and intentional nonadherence. Long-acting injectable aripiprazole was...

PURPOSE Guidelines for adopting and successfully implementing the requirements of the United States Pharmacopeia (USP) chapter 797 for compounding sterile preparations are presented. SUMMARY The quality of a compounded sterile preparation (CSP) is directly related to the methods used to ensure that the CSP achieves the desired goal of purity, potency, and sterility. A properly designed, const...

The preparation and observations of spheroplast W303 cells are described with Environmental Scanning Electron Microscope (ESEM). The spheroplasting conversion was successfully confirmed qualitatively, by the evaluation of the morphological change between the normal W303 cells and the spheroplast W303 cells, and quantitatively, by determining the spheroplast conversion percentage based on the OD...

The Expert Committee on Specifications for Pharmaceutical Preparations works towards clear, independent and practical standards and guidelines for the quality assurance of medicines. Standards are developed by the Committee through worldwide consultation and an international consensus-building process. The following new guidelines were adopted and recommended for use: procedure for adoption of ...

BACKGROUND Although many catheter-related bloodstream infections (CRBSIs) are preventable, measures to reduce these infections are not uniformly implemented. OBJECTIVE To update an existing evidenced-based guideline that promotes strategies to prevent CRBSIs. DATA SOURCES The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for ...

Before carrying out a respiration study on detached roots, it was necessary to work out a method for obtaining root tissues free from microorganisms. This was essential because fungi give off considerable carbon dioxide in respiration; and the production of respiratory carbon dioxide by asterile roots may be entirely masked by the presence of these microorganisms. Following the method outlined ...