Determinations of steroid receptors have been used to predict steroid sensitivity in various neoplastic tumors. It appears, however, that simple steroid binding measure ments are not sufficient for that purpose in lymphoid tumors. This conclusion is based on a literature survey showing, first, that numerous factors are capable of mod ulating cellular steroid receptor content; second, that the r...

Treatment of dense deposit disease (DDD) has not been established yet. Steroid therapy is considered as ineffective for DDD. We report an 8-year-old girl with DDD in whom steroid pulse therapy with subsequent oral steroid therapy led to disease remission. Serum C3 level improved in accordance with the amelioration of clinical signs. This case suggests that steroid pulse therapy with subsequent ...

A long-standing conundrum of glucocorticoid receptors has been why the steroid binding domain is active in hybrid proteins but not in isolation. For this reason, the precise boundaries of the steroid binding domain have not been defined. These questions have now been systematically examined with a variety of receptor deletion constructs. Plasmids encoding amino acids 537-673 and 537-795 of the ...

Purpose: Idiopathic nephrotic syndrome (INS) is a common glomerular disease observed in children. Depending on their response to steroids, patients can be classified either as having steroid-sensitive (SSNS) or steroid-resistant (SRNS). Whereas SSNS respond favorably steroid treatment and achieve complete remission with normal renal functions, SRNS do not, are at high risk of developing end-sta...

Steroid hormones regulate physiological processes in species ranging from plants to humans. A wide range of steroid hormones exist, and their contributions to processes, such as growth, reproduction, development, and aging, is almost always complex. Understanding the biosynthetic pathways that generate steroid hormones and the signaling pathways that mediate their effects is thus of fundamental...

There are no large studies from Southern India describing the treatment regimen of Duchenne muscular dystrophy which is most common dystrophy. The current observational study aimed to compare steroid versus non-steroid outcomes in diagnosed population South India. Immunohistochemically/genetically confirmed patients between February 2019 and March 2021 were ambispectively included. main assesse...

It is well recognized that steroids are synthesized de novo in the brain (neurosteroids). In addition, steroids circulating in the blood enter the brain. Steroids play numerous roles in the brain, such as influencing neural development, adult neuroplasticity, behavior, neuroinflammation, and neurodegenerative diseases such as Alzheimer's disease. In order to understand the regulation and functi...

to study the effect of dietary animal and plant lipids on gonadal differents and sex steroid hormones levels of blood in rainbow trout (oncorhynchus mykiss), the four diets was formulated based on 15% fat. the control uses 100% oil, fish oil was treated in the first, second and third respectively 25% and 75% fish oil, soybean oil, canola and cotton were used. after six weeks of feeding fish wit...

During the past few years, new immunosuppressants, such as tacrolimus, mycophenolate mofetil (MMF) and basiliximab, have been shown to successfully decrease the incidence of acute rejection, possibly acting as potent substrates for safe steroid withdrawal. Therefore, clinical outcome of 3 months steroid withdrawal, while using the above immunosuppressants, was analyzed. Clinical trial registry ...

BACKGROUND AND OBJECTIVES Corticosteroids are an important contributor to posttransplant hyperlipidemia. Since 2004, we have used a steroid minimization immunosuppression protocol. This study investigated the effect of steroid minimization on dyslipidemia in pediatric renal allograft recipients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Children (<18 years) who underwent renal transplants...