s of presentations given in session 8 of the 2008 UCOWR Conference. This Article is brought to you for free and open access by the Conference Proceedings at OpenSIUC. It has been accepted for inclusion in 2008 by an authorized administrator of OpenSIUC. For more information, please contact [email protected]. Recommended Citation Deksissa, Tolessa, "Fate and Transport of Steroid Hormones in t...

Steroid hormones like estrogen are signalling molecules that are involved in a vast array of physiological processes in many species. Steroid hormone effects can be divided into slow genomic and rapid non-genomic responses. The slow response to steroid hormones is reasonably well understood; it is mediated by soluble, cytoplasmic receptors that enter the nucleus after binding with their ligand,...

The steroid hormones are lipophilic compounds with low molecular weight, derived from cholesterol, which play a crucial role in differentiation, development and physiological functions of many tissues. They are synthesized primarily by endocrine glands, such as the gonads, the adrenal glands and the feto-placental unit during pregnancy. In addition, the central nervous system (CNS) seems to be ...

This paper presents the development, optimization and validation of a methodology to determine nine key steroid hormones (viz. pregnenolone, progesterone, dehydroepiandrosterone, androstenedione, testosterone, dihydrotestosterone, estrone, 17α-estradiol and 17β-estradiol) expressed in the steroidogenesis in biological fluids. The analytical method allows for the determination of steroid hormone...

Steroid hormones synthesized in and secreted from peripheral endocrine glands pass through the blood-brain barrier and play a role in the central nervous system. In addition, the brain possesses an inherent endocrine system and synthesizes steroid hormones known as neurosteroids. Increasing evidence shows that neuroactive steroids protect the central nervous system from various harmful stimuli....

Hydroxysteroid dehydrogenases (HSDs) belong to the NADPH/NAD+-dependent oxidoreductases, which interconvert ketones and the corresponding secondary alcohols. As their names imply, they catalyze the oxidoreduction in different positions of steroidal substrates (3α-, 3β-, 11β-, 17β-, 20αand 20β-position). The steroid-converting HSDs play central roles in the biosynthesis and inactivation of stero...

BACKGROUND Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. METHODS In a nationally representative sample of 1,262 men participating in the morning examination session of phase I (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and ...

BRCA1 mRNA and protein levels are regulated by the steroid hormones estrogen and progesterone in human breast cancer cells. BRCA1 mRNA and protein levels were significantly decreased in estrogen-depleted MCF-7 and BT20T cells and increased again after stimulation with beta-estradiol. The increase in BRCA1 expression upon stimulation with estrogen was not coordinated with the early induction of ...

The synthetic anabolic steroids have structural features which distinguish them from the natural steroid hormones. It should therefore be possible to detect the taking of these substances by testing for their presence in either blood or urine. At present suitable techniques include gas chromatography, mass spectrometry and radioimmunoassay. For practical and psychological reasons urine tests ar...

Steroid hormones are essential for the normal function of most organ systems in vertebrates. Reproductive activities in females and males, such as the differentiation, growth and maintenance of the reproductive system, require signaling by sex steroid hormones. Although extensively studied in mammals and a few fish and bird species, the evolution and molecular mechanisms associated with the nuc...