paris polyphylla smith var. yunnanensis, has been used in traditional chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. in this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the etoh extract of paris polyphylla var. yunnanensis, and then tested for their antit...

The anti-inflammatory effects of the new steroidal antedrug, 21-acetyloxy-9α-fluoro-11β-hydroxyl-3, 20-dioxo-1, 4-pregnadieno-[16α, 17α-d] isoxazoline (FP-ISO-21AC), on nitric oxide (NO) and interleukin 8 (IL-8) production, were investigated together with its parent steroid prednisolone (PRED). PRED is one of the anti-inflammatory steroids but has systemic side effects which limit the use of it...

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common pharmacological group that has three primary therapeutic effects including anti-inflammatory, anti-pyrexia, and analgesia. In this study, seven of NSAIDs were tested against two species of skin pathogenic fungi (dermatophytes). Percentage inhibition was determined for effective agents. Diclofenac, Aspirin and Naproxen showed muc...

Emphysematous gastritis is rare infection of the gastric wall associated with high mortality. Damage mucosal barrier and bacterial translocation can lead to emphysematous gastritis. Non-steroidal anti-inflammatory drugs use one etiological factors. Due mortality rates, early diagnosis treatment important. Patients are presenting emergency departments generally non-specific acute abdominal signs...

Acute and chronic tendon injuries are very common among athletes and in sedentary population. Most physicians prescribe anti-inflammatory managements to relieve the worst symptoms of swelling and pain, including non-steroidal anti-inflammatory drugs, corticosteroids and physical therapies. However, experimental research shows that pro-inflammatory mediators such as prostaglandins may play impor...

BACKGROUND/AIM Steroidal mineralocorticoid receptor antagonists (MRAs) are effective in the treatment of kidney disease; however, the side effect of hyperkalaemia, particularly in the context of renal impairment, is a major limitation to their clinical use. Recently developed non-steroidal MRAs have distinct characteristics suggesting that they may be superior to steroidal MRAs. Therefore, we e...