PURPOSE Although much has been written about the role of the NMDA receptor's role in experience dependent visual plasticity, the function of the NMDAR1 receptor subunit in the post-plasticity stage of development is still not well understood. However, in the well studied model of strabismic amblyopia where binocularity is reduced, but where most primary visual cortex neurons can be driven by on...

PURPOSE To compare the macular and nerve fiber layer thicknesses as measured by optical coherence tomography (OCT) in amblyopic and fellow eyes. METHODS Fifty patients with monocular strabismic (n = 25) or anisometropic (n = 25) amblyopia (best corrected visual acuity (BCVA) ranging from 20/40 to 20/400) were included in a prospective cross-sectional descriptive study. A refractive error more...

PURPOSE. The Dutch population-based child health monitoring program includes regular preverbal (age range, 1-24 months) and preschool (age range, 36-72 months) vision screening. This study is on the contribution of an organized vision screening program to the detection of amblyopia. METHODS. A 7-year birth cohort study of 4624 children was started in 1996/1997 in Rotterdam. Vision screening dat...

Monocular contrast sensitivity (CS) measurements were obtained in the two principal meridians of eight constant unilateral strabismic subjects and four subjects diagnosed with alternating strabismus. The results indicated that: (1) the CS of both the fellow and deviating eyes of patients with a constant unilateral deviation is significantly less than that of visually normal eyes at high spatial...

In order to understand the nature of the neural loss in strabismic amblyopia, we have applied a technique which has been used in the normal periphery to psychophysically probe the sampling properties of the neuronal population. We ask whether there is a 'sampling' deficit and if so whether it is based on either an absolute loss of neurons (i.e. spatial undersampling) or an irregular arrangement...

Visual development depends on sensory input during an early developmental critical period. Deviation of the pointing direction of the two eyes (strabismus) or chronic optical blur (anisometropia) separately and together can disrupt the formation of normal binocular interactions and the development of spatial processing, leading to a loss of stereopsis and visual acuity known as amblyopia. To sh...

Spatial localization was investigated for each eye of amblyopic observers using a bisection paradigm. The stimuli were comprised of a grating composed of bright lines, and a test line. The test line was either placed above the grating (bisection-no overlap) or within the row of lines comprising the grating (bisection-with overlap) and thresholds for each bisection task were measured as a functi...

The treatment of amblyopia, particularly anisometropic (difference in refractive correction) and/or strabismic (turn of one eye) amblyopia has long been a challenge for many clinicians. Achieving optimum outcomes, where the amblyopic eye reaches a visual acuity similar to the fellow eye, is often impossible in many patients. Part of this challenge has resulted from a previous lack of scientific...

We tested the state of retinal correspondence at different positions in the visual field of ten observers with strabismic and/or anisometropic amblyopia, four strabismic subjects with alternating fixation and three normal controls. Correspondence was evaluated by the subjective displacement of dichoptic stimuli; to estimate the displacement, we used red-green filters, Bagolini striated glasses,...