Streptococcus faecalis strains DS-5 and Streptococcus pyogenes strain AC-1 both have a 17 million dalton plasmid that determines resistance to erythromycin, lincomycin, and vernamycin B(alpha). The results of deoxyribonucleic acid-deoxyribonucleic acid hybridization experiments indicate that the two plasmids are about 95% homologous. It was also shown that erythromycin resistance is inducible i...

Bacteria as a source of antibiotic materials have been the object of intensive study. Some of the bacteria more recently investigated for antibiotic properties have been Chromobacterium violaceum by Lichstein and Van de Sand (1945) and the Bacillus subtilis group by various workers, among whom may be mentioned Salle and Jann (1945), Johnson, Anker, and Meleney (1945), Olivier, De Saint Rat, and...

We present the complete genome assembly of Streptococcus pyogenes ATCC 19615 (Rosenbach) as submitted to GenBank under accession number CP008926. This group A nonmotile β-hemolytic clinical isolate is used for quality control in a variety of commercially available tests. The assembled genome is 1.84 Mb (38.5% G+C content) and contains 1,788 coding regions.

Group A Streptococcus (Streptococcus pyogenes), group B Streptococcus (Streptococcus agalactiae) and Streptococcus pneumoniae (pneumococcus) are host-adapted bacterial pathogens among the leading infectious causes of human morbidity and mortality. These microbes and related members of the genus Streptococcus produce an array of toxins that act against human cells or tissues, resulting in impair...

The gram-positive bacterium Streptococcus pyogenes (group A streptococcus) is the causative agent of a wide variety of suppurative infections of cutaneous tissues. Previous analyses have demonstrated that the M protein of S. pyogenes is an adhesin that directs the attachment of the streptococcus to keratinocytes in the skin. In this study, we have examined keratinocyte function in response to S...

Strep throat causing Streptococcus pyogenes was detected in vitro and in simulated clinical samples by performing touch spray ionization-mass spectrometry. MS analysis took only seconds to reveal characteristic bacterial and human lipids. Medical swabs were used as the substrate for ambient ionization. This work constitutes the initial step in developing a non-invasive MS-based test for clinica...

Introduction The acronym PANDAS reveals a pediatric autoimmune neuropsychiatric disorder associated with Streptococcus pyogenes infection. This disorder is defined by: (a) the presence of obsessive-compulsive disorder (OCD) or tics; (b) abrupt onset and remitting/relapsing course; (c) prepuberal onset of all symptoms; (d) temporal association with a group A b-hemolytic S. pyogenes infection; (e...

The use of trimethoprim in treatment of Streptococcus pyogenes infections has long been discouraged because it has been widely believed that this pathogen is resistant to this antibiotic. To gain more insight into the extent and molecular basis of trimethoprim resistance in S. pyogenes, we tested isolates from India and Germany and sought the factors that conferred the resistance. Resistant iso...

We report a case of pneumonia with a fatal outcome caused by a nonhemolytic strain of Streptococcus pyogenes. This strain was isolated in pure growth from blood cultures and was fully identified biochemically. Such strains will be difficult to recognize and isolate from sites with heavy growth of normal flora. This phenomenon has been reported sporadically before, and it is unknown how common s...

Investigations were carried out to study the organisms associated with 80 cases of osteomyelitis at Faisalabad. Seventy eight had infection with single organism; whereas there was no growth in 2 cases. On culture, the frequency of the organisms was Staphylococcus aureus in 30 (37.5%), Streptococcus pyogenes in 28 (35%); Escherichia co/i in 16 (20%); Salmonella in 3 (32%) and Proteus vulgar/s in...