BACKGROUND Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis. METHODS Patients with knee osteoarthritis (Kellgren and Lawrence grade 2 or 3, and joint space width (JSW) 2.5-5 mm) were randomly allo...

STUDIES OF BONE lWABOLISM WITH THE AID OF RADIOACTIVE STRONTIUM by D. e. JonesandD. H. Copp,M.D. January16T 1948 The kinetics of skeletal uptake and urinary excretion of radiostrontium were studied during the critieal first hour following intraperitoneal injection of a carrier-free dose. These experiments not only provided valuable data con.cerning the metabolism and fixation of this important ...

A clinical test of intestinal calcium absorption has been developed using non-radioactive stable strontium as a calcium tracer. In nine elderly subjects there was a close correlation between the fractional absorption of strontium and radioactive calcium (45Ca) during a five hour period after the simultaneous oral administration of the two tracers. Comparable precision was achieved with each tra...

To develop mechanistic models of contaminant distribution processes, we conducted an X-ray absorption fine structure analysis of strontium sorption to hydrous manganese oxide (HMO). Sr K-edge measurements were performed at 298, 220, and 77 K, and at sample loadings from 10(-4) to 10(-2) mol Sr/g HMO. Results from fitting the first shell in the sorbed samples indicate that strontium is surrounde...

AIM A bioanalytical method using inductively-coupled plasma-mass spectrometry to measure endogenous levels of strontium in human serum was developed and validated. RESULTS & METHODOLOGY This article details the experimental procedures used for the method development and validation thus demonstrating the application of the inductively-coupled plasma-mass spectrometry method for quantification ...

A method for determining strontium 90 in environmental materials is described. It consists of the ion-exchange separation of strontium from calcium at an elevated temperature by careful control of pH and the molar ratio of Ca:EDTA, followed by scavenging, Activity of the Sr-90 is determined by counting the yttrium 90 daughter. Recovery of strontium is determined with Sr-85 tracer. Typical recov...

BACKGROUND AND OBJECTIVES Idiopathic hypercalciuria is a frequent defect in calcium kidney stone formers that is associated with high intestinal calcium absorption and osteopenia. Characteristics distinguishing hypercalciuric stone formers from hypercalciuric patients without kidney stone history (HNSFs) are unknown and were explored in our study. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS...

The reaction mixture of magnesium chloride with two equivalents of potassium anthranilate [K+ AnthÐ] in water gives on cooling to 0 ∞C a 60% yield of a precipitate which after drying in a vacuum has the composition [Mg(H2O)6](Anth)2 (1). Recrystallization from hot water affords an octahydrate identified as [Mg(H2O)6](Anth)2(H2O)2 (2) in a single crystal X-ray diffraction study. Contrary to find...

CONTEXT Strontium ranelate reduces vertebral and nonvertebral fracture risk in postmenopausal osteoporosis. OBJECTIVE The objective of this study was to determine the efficacy and safety of strontium ranelate in osteoporosis in men over 2 years (main analysis after 1 year). DESIGN This was an international, unbalanced (2:1), double-blind, randomized placebo-controlled trial (MALEO [MALE Ost...