In the past decade, clinical practice in rheumatology has been transformed by the advent of ‘biologicals’. The use of these new drugs has significantly improved the outcome of patients with rheumatoid arthritis especially for those refractory to (patient-tailored) conventional diseasemodifying antirheumatic drug (DMARD) therapy. The question is, is it now time for a gap-bridging, large step for...

this study was mainly designed to investigate and identify the amounts and types of heavy metals in the soils of national iranian oil refining & distribution company in shahrood region and tried to establish a logical relation between the presence of heavy metals and their damage on vegetation. in addition, considering the power of drained soil and due to the proximity of ground water in shahro...

The unit-cell parameters for the title mixed-metal coordination polymer, {[NiSr(C(3)H(2)O(4))(2)(H(2)O)(5)]·2H(2)O}(n), which is isostructural with its Co-containing analogue, were reported previously [Gil de Muro et al. (1999 ▶). Eur. J. Inorg. Chem. pp. 935-943]; the full crystal structure including a description of the hydrogen bonding is reported here. The Sr(2+) ion is bonded to five O ato...

Spontaneous reossification of the sellar floor after transsphenoidal surgery has been rarely reported. Strontium ranelate, a divalent strontium salt, has been shown to increase bone formation, increasing osteoblast activity. We describe an unusual case of a young patient with Cushing's disease who was treated with strontium ranelate for low bone mass who experienced spontaneous sellar reossific...

A procedure for the preparation of Strontium Hydroxyapatite is adapted to produce high purity and better homogeneity ceramic with good Crystallinity. The strontium substituted bone cement has potential for use in orthopedic surgeries. Ionic Strontium (Sr) in humans shares the same physiological pathway as calcium and can be deposited in the mineral structure of the bone. In the present study, a...

Porous bioactive glasses are attractive for use as bone scaffolds. There is increasing interest in strontium containing bone grafts, since strontium ions are known to up-regulate osteoblasts and down regulate osteoclasts. This paper investigates the influence of partial to full substitution of strontium for calcium on the dissolution and phase formation of a multicomponent high phosphate conten...

We study the nature of the [Ti ii] and [Ni ii] emission from the so-called strontium filament found in the ejecta of η Carinae . To this purpose we employ multilevel models of the Ti ii and Ni ii systems which are used to investigate the physical condition of the filament and the excitation mechanisms of the observed lines. For the Ti ii ion, for which no atomic data was previously available, w...

OBJECTIVE This study was undertaken to assess the effect of strontium ranelate on nonvertebral and vertebral fractures in postmenopausal women with osteoporosis in a 5-year, double-blind, placebo-controlled trial. METHODS A total of 5,091 postmenopausal women with osteoporosis were randomized to receive either strontium ranelate at 2 gm/day or placebo for 5 years. The main efficacy criterion ...

OBJECTIVES Early osteoporotic fractures have a great impact on disease progression, the first fracture being a major risk factor for further fractures. Strontium ranelate efficacy against vertebral fractures is presently assessed in a subset of women aged 50-65 years. METHODS The Spinal Osteoporosis Therapeutic Intervention (SOTI) was an international, double blind, placebo controlled trial, ...

Transhumance and palaeodiet are two central themes in archaeology and using chemical analysis of bones and teeth to reconstruct trends and patterns in diet and mobility has become a cornerstone of bioarchaeology. This study has investigated strontium concentration ([Sr]), radiogenic (Sr/Sr) and stable strontium (δSr) isotope systematics in a controlled feeding experiment on domestic pigs design...