matrix metalloproteinases (mmps) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. mmps have been demonstrated to increase the permeability of the blood–brain barrier (bbb) by degrading the compone...

although the genome is defined by its primary sequence, its functional properties, are determined by far more complex mechanisms and depend on multiple layers of nuclear organization. the architecture of the nucleus includes two overlapping structures: the chromatin and a framework structure named the nuclear matrix. ultra-structural studies reveal that the nuclear matrix is a network consistin...