Subacute toxicity study of acetamiprid was undertaken in 72 female Wistar rats randomly divided into four groups (each consisting of 18individuals). Acetamiprid was administered orally @ 0, 25, 100 and 200 mg/kg of body weight to rats of Groups 1, 2, 3 and 4 respectively. Group 1 served as control. Calcium, sodium, potassium, chloride, zinc, copper, iron and cobalt were significantly increased ...

A 51 year old man developed progressive cranial and proximal muscle weakness, hyperreflexia and mental change. The disorder progressed over 9 days following the fifth weekly spraying with the organophosphate (OP) insecticide, phosmet, with limited symptoms of acute toxicity. Marked decremental responses of 50-80% on slow and fast rates of stimulation were improved to 15% by edrophonium or neost...

The first part of this report is devoted to recalling some very general concepts— indispensable for the understanding of the problems involved: 1. Concerning the different kinds of toxicity, acute, subacute, short term and long term, with special consideration of the consequences, mostly very insidious, of repeated exposure to poisons with cumulative properties. 2. Concerning the processes of a...

The management of diabetes is considered a global problem. FS002, a polyherbal Siddha formulation intended to be used for diabetic patients, has been screened for toxic effect. For sub-acute toxicity studies, different doses of FS002 were administered orally to rats once daily for 30 days. Animals were observed for physiological and behavioral responses, mortality, food, water intake and body w...

The present study was aimed at investigating the safety of Lacidipine (LCDP) loaded nanostructured lipid carriers (NLCs) in Wistar rats. NLCs were formulated using ultrasound dispersion technique. Animals were orally treated once daily with NLCs containing 0.140 mg, 0.350 mg, and 0.875 mg of LCDP as low, medium, and high dose per kg body weight, respectively, during 28 days along with blank for...

Objective: The aim of this study was to investigate the toxicity; analgesic and anti-pyretic properties of standardized HA methanolic extract (HAMeOH) in vivo. Methods: The acute toxicity study was performed on rats while adopting the OECD-420 Guidelines (fixed dose procedure). Assessment of analgesic activity was performed in rats with two analgesic models. One was acetic acid induced writhing...

AIM The aim was to evaluate the effect of multiple oral administration of bisphenol A (BPA) for 28 days on seminal characteristic on mammal using Wistar rat as a model. MATERIALS AND METHODS Rats were randomly divided into five different groups having 6 male rats in each group. The doses chosen were 50, 200, and 600 mg/kg body weight for Groups III, IV and V, respectively, based on preliminar...

The new synthesized N-substituted-benzamides are structurally related to tiapride, sulpiride or amisulpride, drugs mainly used in the treatment of psychosis and depressive states. This dual activity is based on the dose-dependent antagonist properties towards dopamine receptors. At low antidepressant doses, benzamides preferentially block presynaptic dopamine D3 autoreceptors, that control dopa...

Acute and sub-acute toxicity of ethanolic extract (ETE) of C. mannii was assessed on white mice (Mus musculus). After 48 h of extract administration, no death was registered. It was deduced that the LD50 was indisputably higher than 16 g/kg body weight. The sub-acute toxicity test was based on the daily administration of three doses of ETE (300, 600 and 1200 mg/kg body weight) for four weeks; 1...