BACKGROUND AND OBJECTIVES This study evaluates the efficacy and safety of a sufentanil sublingual tablet system (SSTS) for the management of postoperative pain following open abdominal surgery. METHODS At 13 hospital sites in the United States, patients following surgery with pain intensity of greater than 4 on an 11-point numerical rating scale were randomized to receive SSTS dispensing a 15...

The current gold standard for treating postpartum hemorrhage (PPH) due to atony is intravenous (IV) oxytocin1. However, access to this specific drug and the capacity for its timely intravenous administration are lacking in settings with limited resources, especially at lower levels of the health care system. Misoprostol, a tablet that requires no additional supplies and/or specialized skills to...

We want to compare the efficacy and safety of vaginal versus sublingual misoprostol for cervical ripening and induction of labor. This randomized clinical trial was performed on 140 women with medical or obstetric indications for labor induction. The patients were randomly divided into two groups: vaginal and sublingual administration of misoprostol. In first group, 25 µg misoprostol was placed...

Abstract Background A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life patients and is associated with high socioeconomic burden. The most common symptoms include runny nose nasal congestion, sneezing, itching nose, mouth and/or throat, ocular symptoms. Affected often develop bronchial asthma. Therapy options for allergen avoidance, symptomatic tr...