Minimum inhibitory concentrations of lactic acid bacteria and other antagonist microorganisms isolated from natural sources Kaliningrad region (soil, water bodies, plant objects) were determined. It was shown that the minimum concentration Pediococcus pentosaceus metabolites against Escherichia coli is 1.5·107 CFU/ml; Pseudomonas chlororaphis have no effect test strain under study . found damno...

BACKGROUND Despite the efficacy of highly active antiretroviral treatment (HAART), a large proportion of human immunodeficiency virus (HIV)-infected patients may develop moderate neurocognitive impairment. Antiretroviral drug passage into the central nervous system may be relevant for preventing and treating HIV-associated neurocognitive disorder; nevertheless, clear cerebrospinal fluid (CSF) p...

introduction: although bacteria producing biofilm are more resistance to antimicrobial agents, biofilm formation can stimulated by sub-minimal inhibitory concentrations (sub-mics) of some antimicrobial agents. therefore, we designed present study to investigate the  in vitro efficacy of several antibiotics (including ceftazidime, piperacillin, ticarcillin, carbenicillin, aztreonam, meropenem, g...

background and objectives: current chemotherapies of cutaneous leihmaniasis have faced to some problems and limitations; development of new leishmanicidal drugs from different sources like herbal plants, are crucially important. the objective of the present study was evaluation of in vitro activity of alkanna frigida extracts in comparison with glucantime against leishmania major . materials an...

The inhibitory effect of chloramphenicol on human cytochrome P450 (CYP) isoforms was evaluated with human liver microsomes and cDNA-expressed CYPs. Chloramphenicol had a potent inhibitory effect on CYP2C19-catalyzed S-mephytoin 4'-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation, with apparent 50% inhibitory concentrations (inhibitory constant [K(i)] values are shown in parentheses)...

NK cells can co-express inhibitory and activating killer Ig-like receptors (KIR) recognizing the same HLA class I ligand. We present evidence from experiments with NK cells expressing both activating (KIR2DS2) and inhibitory (KIR2DL2 and KIR2DL3) receptors that the activating KIR can function without apparent interference from the inhibitory KIR. These studies used CD158b mAb that is equally re...

IN THE TWO PRECEDING PAPERS it was reported that gamma-aminobutyric acid (GABA) was the most active of ten blocking substances extracted from the nervous systems of lobsters and crabs. The concentrations of GABA in several peripheral nerves were measured and found to be highest in a nerve that contained only one motor and one inhibitory axon. It was natural to wonder if GABA was specifically co...

The use of dilutions differing by small arithmetic increments was studied as a means for improving the definition and measurement of minimum inhibitory concentrations and precision parameters for testing Pseudomonas aeruginosa versus the aminoglycosides by the broth microdilution test. For five strains of P. aeruginosa versus gentamicin, tobramycin, and amikacin, comparisons were made of minimu...