نتایج جستجو برای: substrate inhibition
تعداد نتایج: 456722 فیلتر نتایج به سال:
We provide optimal feed trajectories for fedbatch fermentation of microorganisms with substrate inhibition kinetics. demonstrate that the are non-unique and analytical procedures solving control problem. Since, this is essential practical operations as a numerical solution could be any feasible solutions. In addition, we investigate sensitivity bang-bang from point view. This insight relevant m...
Introduction: α-amylase is a major form of amylase found in humans and other mammals. It is the special key enzyme involved in carbohydrates breakdown. Inhibition of this enzyme could be used in treatment of diabetes. In this study, the effect of ten Iranian macrolichens on alpha amylase were tested. Methods: Different concentrations of the extracts (25, 50 and 75 mg/ml) were incubated wi...
Understanding the substrate recognition mechanism of γ-secretase is a key step for establishing substrate-specific inhibition of amyloid β-protein (Aβ) production. However, it is widely believed that γ-secretase is a promiscuous protease and that its substrate-specific inhibition is elusive. Here we show that γ-secretase distinguishes the ectodomain length of substrates and preferentially captu...
Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian target of rapamycin (mTOR) involves in various cellular processes including autophagy, apoptosis and energy metabolism. Recently, studies have been shown an association between mTOR pathway and inflammation, supporting the role of the pathway in the pathogenesis of infla...
We developed an in vitro high-throughput cocktail assay with nine major drug-metabolizing CYP enzymes, optimized for screening of time-dependent inhibition. The method was applied to determine the selectivity CYP2C8 inhibitors gemfibrozil 1-O-?-glucuronide and clopidogrel acyl-?-D-glucuronide. In incubations selective probe substrates pooled human liver microsomes were conducted 96-well plates ...
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