Quercetin and daidzin are flavonoid glycoside type compounds that have been found in many plants nutraceuticals. This study aims to examine the vitro cytotoxic selectivity properties of quercetin on breast cervical cancers their molecular interaction stability epidermal growth factor receptor tyrosine kinase (EGFR-TK) by applying docking dynamics (MD) simulations. In anticancer activity was per...

The effect of the flavonoid quercetin on epithelial chloride secretion has been studied in vitro. These studies were performed using monolayers of the human colonic epithelial cell line T84, mounted in modified Ussing chambers. Chloride secretion was assessed as changes in short circuit current (I(SC)) both in basal conditions as well as in response to different secretagogues: carbachol (100 mi...

Background and objectives: Plants belonging to the genus Tilia L. (Tiliaceae) are often tall beautiful trees which are considered for various medicinal potentials of their flowers and leaves. The present study was an attempt to investigate the phytochemical constituents of Tilia rubra subsp. caucasica leaves from the hyrcanian forests of north of Iran. Methods: Chroma...

This work aims at studying the optimization of microwave-assisted extraction (MAE) and pressurized liquid extraction (PLE) by multi-response surface methodology (RSM) to test their efficiency towards the extraction of phenolic compounds from Moringa oleifera (M. oleifera) leaves. The extraction yield, total phenolic content (TPC), total flavonoid content (TF), DPPH scavenging method and trolox ...

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumption. Valid biomarkers of flavonoid intake may be useful for estimating exposure in a range of settings. However, to date, few useful flavonoid biomarkers have been identified. In this study, we used ...

Studies have suggested that dietary flavonoids are helpful in the prevention of atherosclerosis and cardiovascular disease. Antioxidant activity should be noted as underlying mechanism of their health impact in the vascular system, as atherosclerosis is closely related to oxidative events such as oxidized LDL accumulation in the macrophages. Vegetables contain a variety of flavonoids, such as f...

This study describes the isolation of a flavonoid fraction from leaves of Ocotea notata (Nees & Mart.) Mez, Lauraceae, the identification of six major compounds (an A-type proanthocyanidin trimer [3], isoquercitrin [4], reynoutrin [5], miquelianin [6], quercitrin [7], afzelin [8]) and four minor compounds (catechin [1], epicatechin [2], quercetin [9], kaempferol [10]) present in the fraction an...

Miguel Payá , Salvador Máñez, and Angel Villar Departamento de Farmacognosia y Farmacodinamia Facultad de Farmacia, Universidad de Valencia, Avda. Blasco Ibanez, 13, 46010 Valencia, Spain Z. Naturforsch. 41c, 976—978 (1986); received June 12/July 22, 1986 Rhamnus lycioides, Flavonoids From the aerial part of Rhamnus lycioides, which is used in folk medicine in eastern Spain as an antihypertensi...