The crystallization of an organic compound can produce a mixture of crystalline solids with different solid-state structures (polymorphs). No convenient method now exists to separate crystals of a single polymorph from a mixture of crystals of different polymorphs. Of the physical properties that might be used to separate polymorphs, density is attractive for two reasons: 1) Different packings ...

A Hindu male, aged 25, was given sulphathiazole for nasal sinusitus after a common cold; first dose (4 tablets) given at night. Late at night he woke up with itchiness of the scalp and in the morning he had puffiness and oedema of the face and scalp (giving a wrinkled baggy appearance to the face). It was soon relieved by an injection of adrenalin. No more of the sulpha-drug was taken.' A year ...

Natural products have numerous medicinal applications and play important roles in the biology of the organisms that accumulate them. Flavonoids are one large group of natural products with a diverse number of functions in plants and in human health. The isolates of the flowers of Ipomoea carnea (Family: Convolvulaceae) was screened for wound-healing activity on the male wistar rats by Excision ...

The value of some of the sulphanilamide derivatives in the treatment of plague has now been well recognized. In a field trial conducted at Bettiah, Bihar, in 1940, it was found that both sulphathiazole and sulphapyridine reduced the case mortality in bubonic plague to a significant extent. These results were confirmed in subsequent trials carried out at Latur in 1940 and 1941. Sulphadiazine, an...

1. Strains of staphylococci produce diazotizable materials which can be converted to a dye, and the intensity of the color reaction can be quantitated in the same manner as p-aminobenzoic acid. The sulfonamide-resistant strains which we have studied produce more diazotizable substance than non-resistant strains. 2. The development of a color by the diazotizable substance can be inhibited by exp...

Secondary sulfonamides (4a-8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.1.11.1.7), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study...

The occurrence and distribution of five groups of antibiotics were investigated in the surface sediments of the Yangtze Estuary over four seasons. Four tetracyclines (TCs), sulfaquinoxaline (SQ), enrofloxacin (EFC) and thiamphenicol (TAP) were detected in all the samples, while sulfamerazine (SM) and sulfathiazole (ST) showed the lowest detection frequency. The detection frequencies and antibio...

The corrosion inhibition of carbon steel in 1.0 mol L HCl in the presence of an antibacterial sulfa drug Sulfathiazole, IUPAC name 4-amino-N-(1,3-thiazol-2-yl) benzene sulfonamide (TBSA) was investigated using mass loss and electrochemical measurements such as: potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). Surface chemistry was analyzed by X-ray photoelectron sp...

INTRODUCTION The concept of chemoprevention (use of natural or synthetic compounds to prevent cancers) has great appeal. N-nitroso compounds are mutagens which can be formed in vivo due to the reaction between amides and/or amines with nitrite (1). L-ascorbic acid (asc.) and green tea polyphenols can react with nitrite diminishing or removing the nitrosation risk. Sulfonamides, widely used by t...