Enantioselective modification of sulfonamides and sulfonamide-containing drugs via carbene organic catalysis is disclosed. The cation?? interaction was computationally found to play a pivotal role in modulating the reaction enantioselectivity.

Introduction: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are used in treating pathologic conditions such as fever, pain and inflammation by inhibiting cyclooxygenase and consequently prostaglandin production. Recently , the discovery of different isoforms of this enzyme, Cyclooxygenase-1 (COX-1) and Cyclooxygense-2 (COX-2), has led to the synthesis and introduction of novel drugs with selec...

Two sulfonamide derivatives of tris(aminoethyl)amine selectively facilitate the translocation of a fluorescent phospholipid probe containing the phosphoethanolamine head-group across vesicle membranes.

Alkyne-modified biomolecules can be immobilized site- and chemoselectively on sulfonylazide slides under very mild conditions by means of the click sulfonamide reaction.

Huanglongbing (HLB) is a serious citrus disease that threatens the citrus industry. In previous studies, sulfonamide antibiotics and heat treatment suppressed 'Candidatus Liberibacter asiaticus' (Las), but did not completely eliminate the Las. Furthermore, there are few reports studying the bacterial microbiome of HLB-affected citrus treated by heat and sulfonamide antibiotics. In this study, c...

Demonstration of the fact that strains of pneumococci may become resistant to the antibacterial action of the sulfonamide drugs has emphasized one of the potential difficulties that may arise in the chemotherapy of pneumonia. Not only has the acquisition of drug-fastness been induced by laboratory procedures (1 to 3) but individual strains of pneumococci obtained from patients have exhibited th...

Abstract The class of heterocyclic compounds exhibits a variety pharmacological actions, long employed as an active ingredient in drug design and production. Indole its derivatives are crucial medicinal chemistry. Due to physiological action, it has been gaining lot interest by exhibiting antibacterial, anticonvulsant, antifungal, antimalarial, antidiabetic, antidepressant, anticancer, antimicr...

The presence of antibiotics in crops is mainly caused by their irrigation with reclaimed wastewater and the use organic amendments animal origin. During this work, fate sulfonamide tomato crop has been assessed two commercial greenhouses located Almería (Spain) irrigated wastewater. Samplings were made annually for years. Sulfonamides several parts plant (roots, leaves fruits) as well wastewate...