Disease heterogeneity presents a formidable challenge for clinical medicine. We are unlikely to develop successful, targeted treatments unless diagnostic schemes begin to reflect the biological complexity underlying superficially similar disease phenotypes. To address heterogeneity, there is an increasing recognition that realistic disease models need to be built on a foundation of quantitative...

This paper examines inference and aggregation problems that can ariee in multilevel relational database systems and points out some fallaciee in our thinking about these problems that may hinder real progrees from being made toward their solution. Although others have done come initial research toward solving inference problems, aggregation has been treated only superficially in the literature....

Homogenates of gut and mesenteric lymph node tissue from patients with Crohn's disease, ulcerative colitis, and control patients were tested for cytopathic effect (CPE) production in a series of cell lines including rabbit ileal and W138 cells. A CPE was produced in W138 cells by tissue homogenates from patients with Crohn's disease, ulcerative colitis, and control patients. Evidence was obtain...

A new species of the eucerine bee genus Tetraloniella Ashmead (Apinae: Eucerini) is described and figured from central Saudi Arabia and Qatar. Tetraloniella (Tetraloniella) persiciformissp. n. is distinguished on the basis of coloration, integumental sculpturing, male metafemoral structure, and male terminalia. A floral record of Pulicaria undulata (L.) C.A. Mey. (Compositae) is noted for some ...

"general medical and paramedical readers." A book of this sort frequently emphasizes the interests of the authors. More useful perhaps would be the undertaking of some of the major psychiatric journals of annotated bibliographies of the yearly research in these areas where those who are interested, whether deeply or superficially, can select what they want. In the meantime until there are more ...

Intentionalism is the claim that the phenomenological properties of a perceptual experience supervene on its intentional properties. The paper presents a counterexample to this claim, one that concerns visual grouping phenomenology. I argue that this example is superior to superficially similar examples involving grouping phenomenology offered by Peacocke (1983), because the standard intentiona...

In this paper we state that health economics is now amongst the leaders in a «paradigm shift» in economics that needs to spread as quickly as possible into the rest of the subject. This conclusion is obtained from considering that economics can be applied to topics that do not appear superficially to be economic topics such as what is the best treatment for a national health service to offer to...

Using a currently employed linear accelerator, our intent was to inactivate peroxidase/catalase in tumor tissue by the application of hydrogen peroxide, which is degraded to produce oxygen, thus re-oxygenizing the tumor tissue. In this way, we can convert radioresistant tumors into radiosensitive ones. On the basis of this strategy, we previously developed a new enzyme-targeting radiosensitizat...

Ogleus pilarae n. gen., n. sp. (Leptocheliidae) is described from specimens collected at a depth of 28 m off the eastern coast of Puerto Rico. Morphologically the new genus appears to have its closest affinities with the type species of Heterotanais and those of the two subgenera belonging to Pseudonototanais sensu Guţu. Ogleus is distinguished from these and other leptocheliids by a combinatio...

Percutaneous transvenous mitral annuloplasty (PTMA) has evolved as a latest procedure for the treatment of functional mitral regurgitation. It reduces mitral valve annulus (MVA) size and increases valve leaflet coaptation via compression of coronary sinus (CS). Anatomical considerations for this procedure were elucidated in the present study. In 40 formalin fixed adult cadaveric human hearts, r...