OBJECTIVE To determine the efficacy and safety of supplemental therapeutic oxygen for infants with prethreshold retinopathy of prematurity (ROP) to reduce the probability of progression to threshold ROP and the need for peripheral retinal ablation. METHODS Premature infants with confirmed prethreshold ROP in at least 1 eye and median pulse oximetry <94% saturation were randomized to a convent...

Brain imaging studies in man and single cell recordings in monkey have suggested that medial supplementary motor areas (SMA) and lateral pre-motor areas (PMA) are functionally dissociated concerning their involvement in internally driven and externally cued movements. This dichotomy, however, seems to be relative rather than absolute. Here, we searched for further evidence of relative differenc...

Discussing the risks and benefits of hormone therapy with a doctor is vitally important because well-designed clinical trials of hormone therapy in HIV-negative women have found some unfavourable effects. For instance, data from large randomized clinical trials have found that supplemental estrogen can help relieve some symptoms of menopause. However, some doctors suggest that antidepressants, ...

Numerous neuroimaging studies have shown structural and functional changes resulting from musical training. Among these studies, changes in primary sensory areas are mostly related to motor functions. In this study, we looked for some similar functional and structural changes in other functional modalities, such as somatosensory function, by examining the effects of musical training with wind i...

Supplemental Figure 2 Mapping accuracy as a function of the percentage of uniquely mapped reads Supplemental Figure 3 Methylation call accuracy Supplemental Figure 4 Methylation level accuracy Supplemental Table 1 The results of mapping 10,633,033 real 101-bp long single-end reads from human genome, SRR306435, mate 1 Supplemental Table 2 The results of mapping 1M real 101-bp long paired-end rea...

abstract : dens invagination (di) is a developmental abnormality of teeth which frequently results in a complex internal anatomy of the root canal system. di type 3 is an anomaly characterized by infolding of enamel and dentin extending into the root apex. this may present difficulties when forming a diagnosis and treatment plan. many treatment modalities have been presented in case reports for...

abstract : a 28-year old patient was referred for endodontic treatment of his left mandibular second molar. the patient had no history of systemic diseases and his chief complaint was spontaneous pain in left posterior region of mandible. clinically, there was a deep caries in the left mandibular second molar. radiographic examination of this tooth revealed a long crown containing large pulp ch...

although the delayed exfoliation of primary teeth among children is a common dental problem, simultaneous presence of primary teeth and corresponding successors is a rare feature in adults. this paper reports an unusual case in which both permanent teeth (molars, premolars, and canines) and primary teeth were present simultaneously. this report describes questions concerning the etiology of ove...

background. efficient canal preparation is the key to successful root canal treatment. this study aimed to assess the cleaning and shaping ability, preparation time and file deformation of rotary, reciprocating and manual instrumentation in canal preparation of primary molars. methods. the mesiobuccal canals of 64 extracted primary mandibular second molars were injected with india ink. the samp...

background and aims. the majority of failures in class ii amalgam restorations occur in the first primary molar teeth; in addition, use of compomer instead of amalgam for primary molar teeth restorations is a matter of concern. the aim of the present study was to compare the success rate of class ii compomer and amalgam restorations in the first primary molars. materials and methods. a total of...