OBJECTIVE To describe neuronal firing patterns observed during human spontaneous interictal epileptiform discharges (IEDs) and responses to single pulse electrical stimulation (SPES). METHODS Activity of single neurons was recorded during IEDs and after SPES in 11 consecutive patients assessed with depth EEG electrodes and attached microelectrodes. RESULTS A total of 66 neurons were recorde...

Suppression of host-cell-mediated immunity is a hallmark feature of Yersinia pseudotuberculosis infection. To better understand this process, the interaction of Y. pseudotuberculosis with macrophages and the effect of the virulence plasmid-encoded Yersinia tyrosine phosphatase (YopH) on the oxidative burst was analyzed in a chemiluminescence assay. An oxidative burst was generated upon infectio...

With the help of tachyonic trapping mechanism one can potentially solve a number problems affecting quintessential inflation models. In this we introduce field with spontaneous symmetry breaking potential. When inflaton passes critical point, sudden burst particle production is able to reheat Universe and trap away from theminimum its However, self-interactions suppress reduce efficiency proces...

Despite the fundamental function of neutrophils (polymorphonuclear leukocytes (PMNs)) in innate immunity, their role in Escherichia coli K1 (EC-K1) -induced meningitis is unexplored. Here we show that PMN-depleted mice are resistant to EC-K1 (RS218) meningitis. EC-K1 survives and multiplies in PMNs for which outer membrane protein ...

Processing complex sensory environments efficiently requires a diverse array of neural coding strategies. Neural codes relying on specific temporal patterning of action potentials may offer advantages over using solely spike rate codes. In particular, stimulus-dependent burst firing may carry additional information that isolated spikes do not. We use the well characterized electrosensory system...

Inside individual cells, expression of genes is stochastic across organisms ranging from bacterial to human cells. A ubiquitous feature of stochastic expression is burst-like synthesis of gene products, which drives considerable intercellular variability in protein levels across an isogenic cell population. One common mechanism by which cells control such stochasticity is negative feedback regu...

Early myoclonic encephalopathy (EME) is a rare malignant epileptic syndrome. The erratic myoclonus with or without focal motor seizures, onset before 3 months of age, and persistent suppression-burst pattern in electroencephalograph (EEG) are accepted as the diagnostic criteria for EME. We report an 11 month old infant with EME which was secondary to non-ketotic hyperglycinemia.

Midbrain dopaminergic (DA) neurons in vivo exhibit two major firing patterns: singlespike firing and burst firing. The firing pattern expressed is dependent upon both the intrinsic properties of the neurons and their excitatory and inhibitory synaptic inputs. Experimental data suggest that the activation of NMDA and GABAA receptors is a crucial contributor to the initiation and suppression of b...

Midbrain dopaminergic (DA) neurons in vivo exhibit two major firing patterns: single-spike firing and burst firing. The firing pattern expressed is dependent on both the intrinsic properties of the neurons and their excitatory and inhibitory synaptic inputs. Experimental data suggest that the activation of N-methyl-D-aspartate (NMDA) and GABAA receptors is a crucial contributor to the initiatio...

Electrochemical etching of semiconductors gives rise to a wide variety of self-organized structures including fractal structures, regular and branching pores. The Current-Burst Model and the Aging Concept are considered to describe the dynamical behavior governing the structure formation. Here the suppression of side-branching during pore growth is demonstrated by an open-loop-control method, r...