نتایج جستجو برای: suppressive function

تعداد نتایج: 1223809  

Journal: :Current Biology 2005
Angela M. Thornton

First discovered... The existence of T regulatory cells was first suggested by several animal models in the 1970s. Organ-specific autoimmunity was found to be induced in specific strains of mice that had been thymectomized 3 days after birth but not after thymectomy at 0 or 7 days. It was proposed that self-reactive T cells emerged from the thymus immediately after birth but that there existed ...

2014
Delphine Gitenay Hélène Lallet-Daher David Bernard

Cellular senescence is activated by numerous cellular insults, in particular those driving cancer formation, resulting in stable proliferation arrest and acquisition of specific features. By self-opposing to oncogenic stimulation, senescence is considered as a failsafe program, allowing, when functional, to inhibit cancers occurrence. Compelling evidences suggest a tumor suppressive activity of...

Journal: :International immunology 2009
Shimon Sakaguchi Kajsa Wing Yasushi Onishi Paz Prieto-Martin Tomoyuki Yamaguchi

Regulatory T cells (Tregs), either natural or induced, suppress a variety of physiological and pathological immune responses. One of the key issues for understanding Treg function is to determine how they suppress other lymphocytes at the molecular level in vivo and in vitro. Here we propose that there may be a key suppressive mechanism that is shared by every forkhead box p3 (Foxp3)(+) Treg in...

2013
Xinghui Li Zhen Liu Xiaoli Yan Xiaojun Zhang Yang Li Bao Zhao Shengdian Wang Xuyu Zhou George F. Gao Songdong Meng

Immunization with high-dose heat shock protein gp96, an endoplasmic reticulum counterpart of the Hsp90 family, significantly enhances regulatory T cell (Treg) frequency and suppressive function. Here, we examined the potential role and mechanism of gp96 in regulating immune-mediated hepatic injury in mice. High-dose gp96 immunization elicited rapid and long-lasting protection of mice against co...

Journal: :The Journal of clinical investigation 2013
David Vasquez-Dunddel Fan Pan Qi Zeng Mikhail Gorbounov Emilia Albesiano Juan Fu Richard L Blosser Ada J Tam Tullia Bruno Hao Zhang Drew Pardoll Young Kim

Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including head and neck squamous cell carcinoma (HNSCC). In this study, we characterized CD14+HLA-DR(-/lo) cells sorted from the tumors, draining lymph nodes, and peripheral blood of HNSCC patients. CD14+HLA-DR(-/lo) cells were phenotyped as CD11b+, CD33+, CD34+, arginase-I+, and ROS+. In all 3...

Journal: :The Journal of Experimental Medicine 2007
Qian Yuan Shannon K. Bromley Terry K. Means Krister J. Jones Fumitaka Hayashi Atul K. Bhan Andrew D. Luster

Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the intestine. CD4(+) T lymphocytes play an important role in both initiating and regulating intestinal inflammatory immune responses. CD4(+)CD25(+)CD45RB(low) regulatory T (T reg) cells are capable of preventing the development of colitis in a mouse model of IBD. The precise mechanism of T reg cell-mediated prevention of...

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