نتایج جستجو برای: supratherapeutic
تعداد نتایج: 347 فیلتر نتایج به سال:
BACKGROUND Dabigatran etexilate is a pro-drug of the oral reversible direct thrombin inhibitor dabigatran that interacts with the active site in the catalytic domain of the thrombin molecule. OBJECTIVE To assess the electrophysiological effects of therapeutic and supratherapeutic doses of dabigatran etexilate in healthy subjects, a thorough QT study was performed. METHODS In this single-cen...
Ca2+-influx through L-type Ca2+-channels (LTCCs) is associated with activity-related stressful oscillations of Ca2+ levels within dopaminergic (DA) neurons in the substantia nigra (SN), which may contribute to their selective degeneration in Parkinson's disease (PD). LTCC blockers were neuroprotective in mouse neurotoxin models of PD, and isradipine is currently undergoing testing in a phase II...
ObjectiveWe have reported a case of drug-drug interaction (DDI) involving warfarin and ?-9-tetrahydrocannabinol (THC) that resulted in supratherapeutic international normalized ratio (INR) level. The purpose this report is to highlight the possibility pharmacokinetic DDI between THC warfarin.Case summaryA 67-year-old Caucasian man suffering from chronic pain presented dispensary Buffalo, NY, fo...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید