Grochow et al. (1) questioned the use of body surface area in dose normalization more than a decade ago in this Journal. In this issue, Baker et al. (2) retrospectively assessed the pharmacokinetics of 33 investigational agents tested in phase I trials during the past decade as a function of body surface area in 1650 adult cancer patients. Based on their findings, they recommend that the practi...

At fixed lung volume (VL), alterations in surface tension change alveolar surface area (S) and lung recoil (PL). Wilson (26), using data from fixed lungs (1, 9), quantified the isovolume change in S with PL. We reexamined this question in fresh excised rabbit lungs, with two important differences. First, we measured fractional changes in S by using diffuse light scattering, avoiding the potenti...

preparation of 2-chlorobenzonitrile, and benzonitrile are reported here from the corresponding 2-chlorobenzaldehyde and benzaldehyde by the reaction of ammonium hydroxide/vpo titania, vpo bulk (ammonium metavanadate) cucr catalyst/air system in methanol. all these catalysts showed better conversions with reasonable selectivity to aromatic. the results prove that bet surface area results show vp...